Lactobacillus paracasei CNCM I 1572: A Promising Candidate for Management of Colonic Diverticular Disease

被引：7

作者：

Bretto, Elisabetta ^{[1
,2
]}

D'Amico, Ferdinando ^{[1
,2
,3
]}

Fiore, Walter ^{[4
]}

Tursi, Antonio ^{[5
,6
]}

Danese, Silvio ^{[1
,2
]}

机构：

[1] IRCCS San Raffaele Hosp, Gastroenterol & Endoscopy, I-20132 Milan, Italy

[2] Univ Vita Salute San Raffaele, I-20132 Milan, Italy

[3] Humanitas Univ, Dept Biomed Sci, I-20090 Pieve Emanuele, Italy

[4] Sofar SpA, Via Firenze 40, I-20060 Trezzano Rosa, Italy

[5] Azienda Sanit Locale Barletta Andria Trani, Terr Gastroenterol Serv, I-70031 Andria, Italy

[6] Catholic Univ, Dept Med & Surg Sci, I-20123 Rome, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 07期

关键词：

Lactobacillus paracasei CNCM I 1572; probiotics; acute diverticulitis; diverticular disease; symptomatic uncomplicated diverticular disease; IRRITABLE-BOWEL-SYNDROME; GUT MICROBIOTA; MEDICAL-MANAGEMENT; HEALTH-BENEFITS; NITRIC-OXIDE; PROBIOTICS; BUTYRATE; REMISSION; RIFAXIMIN; BACTERIA;

D O I：

10.3390/jcm11071916

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diverticular disease (DD) is a common gastrointestinal condition. Patients with DD experience a huge variety of chronic nonspecific symptoms, including abdominal pain, bloating, and altered bowel habits. They are also at risk of complications such as acute diverticulitis, abscess formation, hemorrhage, and perforation. Intestinal dysbiosis and chronic inflammation have recently been recognized as potential key factors contributing to disease progression. Probiotics, due to their ability to modify colonic microbiota balance and to their immunomodulatory effects, could present a promising treatment option for patients with DD. Lactobacillus paracasei CNCM I 1572 (LCDG) is a probiotic strain with the capacity to rebalance gut microbiota and to decrease intestinal inflammation. This review summarizes the available clinical data on the use of LCDG in subjects with colonic DD.

引用

页数：12

共 96 条

[1] Irritable bowel syndrome and colonic diverticular disease: overlapping symptoms and overlapping therapeutic approaches [J].