Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease

被引：107

作者：

Merims, Doron ^{[1
]}

Giladi, Nir ^{[1
]}

机构：

[1] Tel Aviv Univ, Dept Neurol, Sackler Sch Med, Tel Aviv Sourasky Med Ctr,Movement Disorders Unit, IL-69978 Tel Aviv, Israel

来源：

PARKINSONISM & RELATED DISORDERS | 2008年 / 14卷 / 04期

关键词：

dopamine dysregulation syndrome; Parkinson's disease; L-dopa; dopamine agonist; gambling;

D O I：

10.1016/j.parkreldis.2007.09.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system malfunction. This may manifest as addiction to L-dopa and behavioral disturbances associated with the impulse control system. These disturbances include: gambling, excessive spending (shopping), hypersexuality and binge eating. We included one such patient's personal story to emphasize the devastating consequences of these potentially reversible phenomena: the patient describes in his own words how gambling induced by an exposure dopamine agonist therapy significantly worsened his disease-related difficulties. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：273 / 280

页数：8

共 81 条

[1]

[Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787

[2] Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation [J].