Irresistible IRES - Attracting the translation machinery to internal ribosome entry sites

被引：227
作者：
Vagner, S [1 ]
Galy, B
Pyronnet, S
机构：
[1] CHU Rangueil, INSERM, U397, F-31403 Toulouse, France
[2] CHU Rangueil, INSERM, U531, Inst Louis Bugnard, F-31403 Toulouse, France
[3] European Mol Biol Lab, D-69117 Heidelberg, Germany
来源：
EMBO REPORTS | 2001年 / 2卷 / 10期
关键词：
D O I：
10.1093/embo-reports/kve208
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.
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收藏
页码：893 / 898
页数：6
相关论文
共 53 条
[1]   Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system [J].
Bergamini, G ;
Preiss, T ;
Hentze, MW .
RNA, 2000, 6 (12) :1781-1790
[2]  
BONNEAU AM, 1987, J BIOL CHEM, V262, P11134
[3]   A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity [J].
Chappell, SA ;
Edelman, GM ;
Mauro, VP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1536-1541
[4]   A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma:: A novel mechanism of oncogene de-regulation [J].
Chappell, SA ;
LeQuesne, JPC ;
Paulin, FEM ;
deSchoolmeester, ML ;
Stoneley, M ;
Soutar, RL ;
Ralston, SH ;
Helfrich, MH ;
Willis, AE .
ONCOGENE, 2000, 19 (38) :4437-4440
[5]   Initiation of Apaf-1 translation by internal ribosome entry [J].
Coldwell, MJ ;
Mitchell, SA ;
Stoneley, M ;
MacFarlane, M ;
Willis, AE .
ONCOGENE, 2000, 19 (07) :899-905
[6]   Identification and characterization of a novel cell cycle-regulated internal ribosome entry site [J].
Cornelis, S ;
Bruynooghe, Y ;
Denecker, G ;
Van Huffel, S ;
Tinton, S ;
Beyaert, R .
MOLECULAR CELL, 2000, 5 (04) :597-605
[7]   Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation [J].
Créancier, L ;
Morello, D ;
Mercier, P ;
Prats, AC .
JOURNAL OF CELL BIOLOGY, 2000, 150 (01) :275-281
[8]   c-myc internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice [J].
Créancier, L ;
Mercier, P ;
Prats, AC ;
Morello, D .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (05) :1833-1840
[9]   Translation driven by an eIF4G core domain in vivo [J].
De Gregorio, E ;
Preiss, T ;
Hentze, MW .
EMBO JOURNAL, 1999, 18 (17) :4865-4874
[10]   Internal ribosome entry site-mediated translation of a mammalian mRNA is regulated by amino acid availability [J].
Fernandez, J ;
Yaman, I ;
Mishra, R ;
Merrick, WC ;
Snider, MD ;
Lamers, WH ;
Hatzoglou, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (15) :12285-12291
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