Tissue Engineering of the Penis

被引:16
作者
Patel, Manish N. [1 ]
Atala, Anthony [1 ]
机构
[1] Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA
来源
THESCIENTIFICWORLDJOURNAL | 2011年 / 11卷
关键词
tissue engineering; regenerative medicine; genitourinary tract; extracellular matrix (ECM); scaffold; penis; ACELLULAR MATRIX GRAFT; BIODEGRADABLE POLYMER SCAFFOLDS; PEYRONIES-DISEASE SURGERY; EMBRYONIC STEM-CELLS; URETHRAL RECONSTRUCTION; SMOOTH-MUSCLE; HUMAN BLADDER; IN-VITRO; VESICOURETERAL REFLUX; HUMAN UROTHELIUM;
D O I
10.1100/2011/323989
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Congenital disorders, cancer, trauma, or other conditions of the genitourinary tract can lead to significant organ damage or loss of function, necessitating eventual reconstruction or replacement of the damaged structures. However, current reconstructive techniques are limited by issues of tissue availability and compatibility. Physicians and scientists have begun to explore tissue engineering and regenerative medicine strategies for repair and reconstruction of the genitourinary tract. Tissue engineering allows the development of biological substitutes which could potentially restore normal function. Tissue engineering efforts designed to treat or replace most organs are currently being undertaken. Most of these efforts have occurred within the past decade. However, before these engineering techniques can be applied to humans, further studies are needed to ensure the safety and efficacy of these new materials. Recent progress suggests that engineered urologic tissues and cell therapy may soon have clinical applicability.
引用
收藏
页码:2567 / 2578
页数:12
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