Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis

被引:36
作者
Shao, Guangying [1 ]
He, Jinzhao [1 ]
Meng, Jia [1 ]
Ma, Ang [1 ]
Geng, Xiaoqiang [1 ]
Zhang, Shun [1 ]
Qiu, Zhiwei [1 ]
Lin, Dongmei [2 ,3 ]
Li, Min [1 ]
Zhou, Hong [1 ]
Lin, Shuqian [2 ,3 ]
Yang, Baoxue [1 ,4 ]
机构
[1] Peking Univ, Sch Basic Med Sci, Dept Pharmacol, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[2] Fuzhou Inst Green Valley Biopharm Technol, Fuzhou 350002, Peoples R China
[3] Fujian Agr & Forestry Univ, JUNCAO Technol Res Inst, Fuzhou 350002, Peoples R China
[4] Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100816, Peoples R China
基金
中国国家自然科学基金; 北京市自然科学基金;
关键词
ganoderic acids; renal ischemia reperfusion injury; acute kidney injury; inflammation; cell apoptosis; hypoxia reoxygenation; ISCHEMIA/REPERFUSION INJURY; PATHOPHYSIOLOGY; MECHANISMS; PATHWAYS;
D O I
10.3390/ijms221910229
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Renal ischemia reperfusion injury (RIRI) is one of the main causes of acute kidney injury (AKI), which can lead to acute renal failure. The development of RIRI is so complicated that it involves many factors such as inflammatory response, oxidative stress and cell apoptosis. Ganoderic acids (GAs), as one of the main pharmacological components of Ganoderma lucidum, have been reported to possess anti-inflammatory, antioxidant, and other pharmacological effects. The study is aimed to investigate the protective effect of GAs on RIRI and explore related underlying mechanisms. The mechanisms involved were assessed by a mouse RIRI model and a hypoxia/reoxygenation model. Compared with sham-operated group, renal dysfunction and morphological damages were relieved markedly in GAs-pretreatment group. GAs pretreatment could reduce the production of pro-inflammatory factors such as IL-6, COX-2 and iNOS induced by RIRI through inhibiting TLR4/MyD88/NF-kB signaling pathway. Furthermore, GAs reduced cell apoptosis via the decrease of the ratios of cleaved caspase-8 and cleaved caspase-3. The experimental results suggest that GAs prevent RIRI by alleviating tissue inflammation and apoptosis and might be developed as a candidate drug for preventing RIRI-induced AKI.
引用
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页数:15
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