Risk factors and the prognosis of sexual dysfunction in male patients with pituitary adenomas: a multivariate analysis

被引:14
作者
Zhou, Wen-Jian-Long [1 ]
Ma, Shun-Chang [2 ]
Zhao, Min [3 ]
Liu, Chang [4 ]
Guan, Xiu-Dong [1 ]
Bao, Zhao-Shi [1 ]
Jia, Gui-Jun [1 ]
Jia, Wang [1 ]
机构
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
[2] Capital Med Univ, Beijing Fuxing Hosp, Dept Neurosurg, Beijing 100045, Peoples R China
[3] Peking Univ Int Hosp, Dept Neurosurg, Beijing 102206, Peoples R China
[4] Univ Chinese Acad Sci, Beijing Huairou Hosp, Dept Neurosurg, Beijing 101400, Peoples R China
基金
中国国家自然科学基金;
关键词
erectile dysfunction; male; pituitary adenomas; sexual dysfunction; testosterone; ERECTILE DYSFUNCTION; CHINESE MEN; PREMATURE EJACULATION; PREVALENCE; DIAGNOSIS; TUMORS; MANAGEMENT; CARCINOMAS; SYMPTOMS; SURGERY;
D O I
10.4103/aja.aja_18_17
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
The impact of sexual dysfunction (SD) is distressing to many male patients with pituitary adenomas which affect both physical and psychological health. The research explored to identify risk factors affecting sexual function and the prognosis of male patients with pituitary adenomas. Two hundred and fifty-four male patients, who aged between 18 and 60 (mean +/- s.d.: 44.16 +/- 10.14) years and diagnosed with pituitary adenomas, were retrospectively analyzed. One hundred and fifty-nine patients (62.6%) complained of SD prior to surgery. The mean International Index of Erectile Function (IIEF-5) in patients with giant adenomas was 16.13 +/- 2.51, much smaller than those with microadenomas or macroadenomas (P < 0.05). All the patients showed significant improvement in terms of erectile dysfunction (ED) following surgery (P < 0.05). In addition, complete resection achieved a higher degree of SD relief than partial resection. The incidence of SD in functioning pituitary adenomas (FPAs) was much higher than that in nonfunctioning pituitary adenomas (NFPAs) (P < 0.05). In addition, compared with NFPAs, males with prolactinomas (82.8%) had the higher prevalence of SD and significantly improvement following surgical intervention (P < 0.05). An inverse relationship was identified between decreasing testosterone levels and increasing incidence of SD before surgery (P < 0.05). There was no significant difference between 6 months and 12 months after surgery in serum testosterone level (P > 0.05). Our results indicated that surgical therapy could be optimized for improvements in SD and that testosterone levels can be used as a sensitive indicator to predict the recovery rate of sexual function in patients with pituitary adenomas following surgery and the serum testosterone level will stay stable in 6 months after surgery.
引用
收藏
页码:43 / 49
页数:7
相关论文
共 30 条
  • [11] Relationship between Sexual Dysfunction and Psychological Burden in Men with Infertility: A Large Observational Study in China
    Gao, Jingjing
    Zhang, Xiansheng
    Su, Puyu
    Liu, Jishuang
    Shi, Kai
    Hao, Zongyao
    Zhou, Jun
    Liang, Chaozhao
    [J]. JOURNAL OF SEXUAL MEDICINE, 2013, 10 (08) : 1935 - 1942
  • [12] Invasive adenoma and pituitary carcinoma: a SEER database analysis
    Hansen, Tara M.
    Batra, Sachin
    Lim, Michael
    Gallia, Gary L.
    Burger, Peter C.
    Salvatori, Roberto
    Wand, Gary
    Quinones-Hinojosa, Alfredo
    Kleinberg, Lawrence
    Redmond, Kristin J.
    [J]. NEUROSURGICAL REVIEW, 2014, 37 (02) : 279 - 285
  • [13] Clinical review: Diagnosis and management of pituitary carcinomas
    Kaltsas, GA
    Nomikos, P
    Kontogeorgos, G
    Buchfelder, M
    Grossman, AB
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (05) : 3089 - 3099
  • [14] Kopczak Anna, 2014, F1000Prime Rep, V6, P5, DOI 10.12703/P6-5
  • [15] The prevalence of premature ejaculation and its clinical characteristics in Korean men according to different definitions
    Lee, S. W.
    Lee, J. H.
    Sung, H. H.
    Park, H. J.
    Park, J. K.
    Choi, S. K.
    Kam, S. C.
    [J]. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 2013, 25 (01) : 12 - 17
  • [16] An analysis of treatment preferences and sexual quality of life outcomes in female partners of Chinese men with erectile dysfunction
    Li, Hong-Jun
    Bai, Wen-Jun
    Dai, Yu-Tian
    Xu, Wen-Ping
    Wang, Chia-Ning
    Li, Han-Zhong
    [J]. ASIAN JOURNAL OF ANDROLOGY, 2016, 18 (05) : 773 - 779
  • [17] Diagnosis and management of pituitary adenomas
    Lleva, Ranee R.
    Inzucchi, Silvio E.
    [J]. CURRENT OPINION IN ONCOLOGY, 2011, 23 (01) : 53 - 60
  • [18] Erectile Dysfunction Is Common among Men with Acromegaly and Is Associated with Morbidities Related to the Disease
    Lotti, Francesco
    Rochira, Vincenzo
    Pivonello, Rosario
    Santi, Daniele
    Galdiero, Mariano
    Maseroli, Elisa
    Balestrieri, Antonio
    Faustini-Fustini, Marco
    Peri, Alessandro
    Sforza, Alessandra
    Colao, Annamaria
    Maggi, Mario
    Corona, Giovanni
    [J]. JOURNAL OF SEXUAL MEDICINE, 2015, 12 (05) : 1184 - 1193
  • [19] Aggressive pituitary tumours: the role of temozolomide and the assessment of MGMT status
    McCormack, Ann I.
    Wass, John A. H.
    Grossman, Ashley B.
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2011, 41 (10) : 1133 - 1148
  • [20] Pituitary adenomas: Surgery and radiotherapy in the age of molecular diagnostics and pathology
    McCutcheon, Ian E.
    [J]. CURRENT PROBLEMS IN CANCER, 2013, 37 (01) : 6 - 37