Role of α7 Nicotinic Acetylcholine Receptors in Synaptic Transmission in Frog Neuromuscular Contacts

被引：0
|
作者：
Lenina, O. A. [1 ]
Kovyazina, I., V [2 ,3 ]
机构：
[1] Russian Acad Sci, Kazan Sci Ctr, Fed Res Ctr, AE Arbuzov Inst Organ & Phys Chem, Kazan, Russia
[2] Russian Acad Sci, Fed Res Ctr, Kazan Sci Ctr, Kazan Inst Biochem & Biophys, Kazan, Russia
[3] Kazan State Med Univ, Minist Hlth Russian Federat, Kazan, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 172卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
acetylcholine; neuromuscular synapse; nicotinic cholinergic receptor; DEPRESSION; PLASTICITY; JUNCTION;
D O I：
10.1007/s10517-022-05427-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The role of alpha 7 nicotinic acetylcholine receptors in coupling of synaptic activity and muscle contractions was studied in frog (Rana ridibunda) neuromuscular synapses. The amplitude of endplate currents, the probability of action potential generation, and the strength of muscle contractions decreased in the presence of selective alpha 7 antagonist methyllycaconitine. The effects of nicotinic acetylcholine receptor blockade depended on the pattern of the motor nerve stimulation. It can be assumed that the muscle action potential is a factor of retrograde control of neurosecretion, which modulates activity of alpha 7 nicotinic receptors and the release of acetylcholine from motor nerve endings.
引用
收藏
页码：534 / 538
页数：5
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