Pyrrolidine synthesis on polystyrene supports: development of a 'one-pot' dipolar cycloaddition strategy

被引：18

作者：

Barrett, AGM ^{[1
]}

Boffey, RJ

Frederiksen, MU

Newton, CG

Roberts, RS

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

[2] Aventis Pharma, Dagenham Res Ctr, Dagenham RM10 7XS, Essex, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 32期

关键词：

cycloaddition; maleimide; solid support; trityl resin;

D O I：

10.1016/S0040-4039(01)01061-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Preparation of substituted pyrrolidines was achieved by solid-phase synthesis via a room temperature 1,3-dipolar cycloaddition of a silver-azomethine ylide, generated in situ, with a polymer-supported maleimide. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5579 / 5581

页数：3

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