GREEN SYNTHESIS OF 2-ARYL-4-PHENYL-QUINAZOLINE DERIVATIVES PROMOTED BY LACTIC ACID

被引：2

作者：

Adrom, Belgheis ^{[1
]}

Hazeri, Nourallah ^{[1
]}

Maghsoodlou, Malek Taher ^{[1
]}

Lashkari, Mojtaba ^{[2
]}

Fatahpour, Maryam ^{[1
]}

机构：

[1] Univ Sistan & Baluchestan, Dept Chem, Fac Sci, POB 98135-674, Zahedan, Iran

[2] Velayat Univ, Fac Sci, Iranshahr, Iran

来源：

MACEDONIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING | 2017年 / 36卷 / 02期

关键词：

green protocol; quinazoline derivatives; multi-component reaction; lactic acid; solvent-free conditions; BIOLOGICAL EVALUATION; IONIC LIQUID; INHIBITORS; DESIGN; 2-PHENYLQUINAZOLINES; LAPATINIB; RECEPTOR;

D O I：

10.20450/mjcce.2017.1137

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An environmentally benign three-component synthetic method is described for the construction of 2-aryl-4-phenylquinazoline derivatives from the reaction between aldehydes, ammonium acetate, and 2-aminobenzophenone in the presence of lactic acid in a solvent-less media. The benefits of the reaction were good yields, a simple procedure, simple starting materials short reaction time, easy work-up, and cleaner reaction profiles.

引用

页码：223 / 228

页数：6

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