Immune-Related Prognostic Model in Colon Cancer: A Gene Expression-Based Study

被引：8
作者：
Yang, Haojie [1 ]
Jin, Wei [1 ]
Liu, Hua [1 ]
Gan, Dan [1 ]
Cui, Can [1 ]
Han, Changpeng [1 ]
Wang, Zhenyi [1 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Dept Coloproctol, Yueyang Hosp Integrated Tradit Chinese & Western, Shanghai, Peoples R China
来源：
FRONTIERS IN GENETICS | 2020年 / 11卷
基金：
中国国家自然科学基金;
关键词：
colon cancer; bioinformatics; immune-related gene; immune cell infiltration; prognostic model; TUMOR-INFILTRATING LYMPHOCYTES; COLORECTAL-CANCER; POOR-PROGNOSIS; CELLS; PROGRESSION; PREDICT; IMPACT; IL-17; TH17;
D O I：
10.3389/fgene.2020.00401
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mounting evidence supports that the malignant phenotypes of cancers are defined not only by the intrinsic activity of tumor cells but also by immune cells that are recruited and activated in tumor-related microenvironment. Here, we developed a diagnostic and prognostic model for colon cancer, based on expression profiles of immune-related genes and immune cell component. As a result, we found that B cell infiltration ratio, CD4(+) T cells, as well as immune-related genes of TRIB3, CHGA, CASP7, LGALS4, LEP, NOX4, IL17A, and HSPD1 may be highly relevant with clinical outcome of colon cancer.
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页数：10
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