A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

被引：6032

作者：

Salmena, Leonardo ^{[1
,2
]}

Poliseno, Laura ^{[1
,2
]}

Tay, Yvonne ^{[1
,2
]}

Kats, Lev ^{[1
,2
]}

Pandolfi, Pier Paolo ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Dept Med, Canc Genet Program,Beth Israel Deaconess Canc Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr,Dept Pathol, Canc Genet Program,Beth Israel Deaconess Canc Ctr, Boston, MA 02215 USA

来源：

CELL | 2011年 / 146卷 / 03期

基金：

澳大利亚国家健康与医学研究理事会; 加拿大健康研究院;

关键词：

NONCODING RNAS; UNTRANSLATED REGION; MICRORNA SPONGES; DOWN-REGULATION; MESSENGER-RNAS; GENE; EXPRESSION; GENOME; PSEUDOGENES; REVEALS;

D O I：

10.1016/j.cell.2011.07.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.

引用

页码：353 / 358

页数：6

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