A grid-based system for microbial genome comparison and analysis

被引:0
作者
Sun, YD [1 ]
Wipat, A [1 ]
Pocock, M [1 ]
Lee, PA [1 ]
Watson, P [1 ]
Flanagan, K [1 ]
Worthington, JT [1 ]
机构
[1] Univ Newcastle Upon Tyne, Sch Comp Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源
2005 IEEE International Symposium on Cluster Computing and the Grid, Vols 1 and 2 | 2005年
关键词
D O I
暂无
中图分类号
TP301 [理论、方法];
学科分类号
081202 ;
摘要
Genome comparison and analysis can reveal the structures and Junctions of genome sequences of different species. As more genomes are sequenced, genomic data sources are rapidly increasing such that their analysis is beyond the processing capabilities of most research institutes. The Grid is a powerful solution to support large-scale genomic data processing and genome analysis. This paper presents the Microbase project that is developing a Grid-based system for genome comparison and analysis, and discusses the first implementation of the system (called MicrobaseLite). MicrobaseLite uses a scalable computing environment to support computationally intensive microbial genome comparison and analysis, employing state-of-the-art technologies of Web Services, notification, comparative genomics and parallel computing. Microbase will support not only system-defined genome comparison and analysis but also user-defined, remotely conceived genome analysis.
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收藏
页码:977 / 984
页数:8
相关论文
共 15 条
[1]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[2]   Evolutionary analysis by whole-genome comparisons [J].
Bansal, AK ;
Meyer, TE .
JOURNAL OF BACTERIOLOGY, 2002, 184 (08) :2260-2272
[3]   Computational proteomics on the Grid [J].
Huedo, E ;
Bastolla, U ;
Montero, R ;
Llorente, IM .
NEW GENERATION COMPUTING, 2004, 22 (02) :191-192
[4]   The superstructure toward open bioinformatics grid [J].
Konagaya, A ;
Konishi, F ;
Hatakeyama, M ;
Satou, K .
NEW GENERATION COMPUTING, 2004, 22 (02) :167-176
[5]  
Krishna A., 2003, P UK E SCI ALL HANDS, P475
[6]   Versatile and open software for comparing large genomes [J].
Kurtz, S ;
Phillippy, A ;
Delcher, AL ;
Smoot, M ;
Shumway, M ;
Antonescu, C ;
Salzberg, SL .
GENOME BIOLOGY, 2004, 5 (02)
[7]   Taverna: a tool for the composition and enactment of bioinformatics workflows [J].
Oinn, T ;
Addis, M ;
Ferris, J ;
Marvin, D ;
Senger, M ;
Greenwood, M ;
Carver, T ;
Glover, K ;
Pocock, MR ;
Wipat, A ;
Li, P .
BIOINFORMATICS, 2004, 20 (17) :3045-3054
[8]   Empirical statistical estimates for sequence similarity searches [J].
Pearson, WR .
JOURNAL OF MOLECULAR BIOLOGY, 1998, 276 (01) :71-84
[9]  
RODRIGUEZ A, 2004, P GLOB GRID FOR 10 W
[10]   IDENTIFICATION OF COMMON MOLECULAR SUBSEQUENCES [J].
SMITH, TF ;
WATERMAN, MS .
JOURNAL OF MOLECULAR BIOLOGY, 1981, 147 (01) :195-197