Effectiveness and safety of long-term antidepressant treatment in bipolar disorder

被引：106

作者：

Ghaemi, SN

Lenox, MS

Baldessarini, RJ

机构：

[1] Harvard Univ, Sch Med, Consoidated Dept Psychit, Boston, MA USA

[2] Harvard Univ, Sch Med, Int Consortium Bipolar Disorders Res, Boston, MA USA

[3] Cambridge Hosp, Bipolar Disorder Res Program, Cambridge, MA 02139 USA

[4] Cambridge Hosp, Psychopharmacol Program, Cambridge, MA 02139 USA

[5] Massachusetts Gen Hosp, Bipolar & Psychot Disorders Program, Belmont, MA USA

[6] Massachusetts Gen Hosp, Psychopharmacol Program, Belmont, MA USA

[7] Massachusetts Gen Hosp, Psychiat Res Labs, McLean Div, Belmont, MA USA

来源：

JOURNAL OF CLINICAL PSYCHIATRY | 2001年 / 62卷 / 07期

关键词：

D O I：

10.4088/JCP.v62n07a12

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Objective: We sought to review research on use of antidepressants for long-term treatment of bipolar depression. Method: We conducted a computerized literature search of the MEDLINE, HealthStar, Current Contents, PsychInfo, and National Library of Medicine databases to identify studies involving antidepressant, anticonvulsant, or lithium use in bipolar disorder or manic-depressive illness published from 1966 through 2000. Results: Only 7 blinded, controlled trials of long-term antidepressant treatment in bipolar disorders were found. The available information is not adequate to support the safety or effectiveness of long-term antidepressant treatment for bipolar depression, with or without mood-stabilizing cotherapy. Conclusion: Antidepressant treatment of bipolar depression is extraordinarily understudied. Controlled trials comparing specific antidepressants, particularly to compare mood-stabilizing agents given alone and combined with an antidepressant, are needed.

引用

页码：565 / 569

页数：6

共 50 条

[41] NOREPINEPHRINE, SEROTONIN AND VESICULAR MONOAMINE TRANSPORTER IN DEPRESSION AND BIPOLAR DISORDER - EXPRESSION DURING LONG-TERM ANTIDEPRESSANT TREATMENT
LESCH, KP
AULAKH, CS
WOLOZIN, BL
RIEDERER, P
MURPHY, DL
NEUROPSYCHOPHARMACOLOGY, 1993, 9 (02) : S34 - S35
[42] Long-term efficacy and safety of lamotrigine for all types of bipolar disorder
Watanabe, Yoshinori
Hongo, Seiji
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2017, 13 : 843 - 854
[43] Defining the role of SGAs in the long-term treatment of bipolar disorder
Malhi, Gin S.
Morris, Grace
Hamilton, Amber
Outhred, Tim
Das, Pritha
BIPOLAR DISORDERS, 2017, 19 (01) : 65 - 67
[44] Long-term treatment of bipolar disorder with a radioelectric asymmetric conveyor
Mannu, Piero
Rinaldi, Salvatore
Fontani, Vania
Castagna, Alessandro
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2011, 7 : 373 - 379
[45] Lithium: still a cornerstone in the long-term treatment of bipolar disorder
Nolen, W. A.
BIPOLAR DISORDERS, 2014, 16 : 25 - 25
[46] Lithium: still a cornerstone in the long-term treatment of bipolar disorder?
Nolen, W.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2013, 23 : S116 - S117
[47] Treating mania and managing long-term treatment of bipolar disorder
Arango, C.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2009, 19 : S713 - S713
[48] Long-term morbidity and mortality considerations in the treatment of bipolar disorder
Newcomer, J.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 : S594 - S594
[49] Lithium: Still a Cornerstone in the Long-Term Treatment in Bipolar Disorder?
Nivoli, Alessandra M. A.
Murru, Andrea
Vieta, Eduard
NEUROPSYCHOBIOLOGY, 2010, 62 (01) : 27 - 35
[50] Long-term treatment of bipolar disorder: The controversial role of antidepressants
Amerio, Andrea
Odone, Anna
Marchesi, Carlo
Ghaemi, S. Nassir
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2014, 48 (11): : 1062 - 1062

← 1 2 3 4 5 →