Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted oxadiazolo pyrrolidin-3-yl-thio)carbapenem derivatives

被引：1

作者：

Oh, CH

Dong, HG

Lee, JS

Lee, SC

Hong, JH

Cho, JH ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Med Chem Res Ctr, Seoul 130650, South Korea

[2] Hawon Pharm Co, Seoul 135080, South Korea

[3] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

来源：

ARCHIV DER PHARMAZIE | 2003年 / 336卷 / 12期

关键词：

1; beta-methylcarbapenem; antibacterial activity; substituent effect;

D O I：

10.1002/ardp.200300768

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of a new series of 1beta-methylcarbapenems with a substituted oxadiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the oxadiazole ring investigated. In particular, compounds 13 a and 13 c with ester and carbamoyl substituted oxadiazole moieties showed the most potent antibacterial activity

引用

页码：567 / 572

页数：6

共 15 条

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