The Evolution of PharmVar

被引：85

作者：

Gaedigk, Andrea ^{[1
,2
]}

Sangkuhl, Katrin ^{[3
]}

Whirl-Carrillo, Michelle ^{[3
]}

Twist, Greyson P. ^{[2
,4
]}

Klein, Teri E. ^{[3
]}

Miller, Neil A. ^{[2
,4
]}

机构：

[1] Childrens Mercy Kansas City, Div Clin Pharmacol Toxicol & Therapeut Innovat, Kansas City, MO 64108 USA

[2] Univ Missouri, Sch Med, Kansas City, MO 64108 USA

[3] Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA

[4] Childrens Mercy Kansas City, Ctr Pediat Genom Med, Kansas City, MO USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2019年 / 105卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1002/cpt.1275

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Pharmacogene Variation Consortium (PharmVar) continues the mission of the Human Cytochrome P450 (CYP) Nomenclature database to provide the clinical and research communities a repository and standardized nomenclature of pharmacogene variation. To improve the utility of this resource, PharmVar has established a database and gene expert panels and expanded beyond CYPs to include other clinically important pharmacogenes. This report describes the evolution from static CYP variation tables to a resource with growing functionality describing pharmacogene variation.

引用

页码：29 / 32

页数：4

共 5 条

[1] The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database [J].