Elevated Serum Levels of CCL17 Correlate with Increased Peripheral Blood Platelet Count in Patients with Active Tuberculosis in China

被引：24
作者：
Feng, Yonghong [1 ]
Yin, Hongyun [1 ]
Mai, Guangliang [1 ]
Mao, Ling [1 ]
Yue, Jun [1 ]
Xiao, Heping [1 ]
Hu, Zhongyi [1 ]
机构：
[1] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Shanghai Key Lab TB,TB Diag & Treatment Ctr, Shanghai 200433, Peoples R China
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2011年 / 18卷 / 04期
关键词：
ACTIVATION-REGULATED CHEMOKINE; MACROPHAGE-DERIVED CHEMOKINE; HUMAN T-CELLS; MYCOBACTERIUM-TUBERCULOSIS; IN-VIVO; THYMUS; EXPRESSION; CYTOKINES; TARC; EOSINOPHILS;
D O I：
10.1128/CVI.00493-10
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The serum levels of Th2 markers, including CCL17 (thymus and activation-regulated chemokine [TARC]), CCL22 (macrophage-derived chemokine [MDC]), and soluble CD30, were measured in 101 HIV-negative tuberculosis patients, 103 healthy community controls, and 18 tuberculosis patients in recovery. The levels of CCL17/TARC (249.8 +/- 19.91 versus 143.9 +/- 10.54, P < 0.0001) and sCD30 (7.78 +/- 0.44 versus 4.93 +/- 0.23, P < 0.0001) were significantly higher in patients with active tuberculosis than in controls; however, the CCL22/MDC serum level had no statistical difference between the groups (579.9 +/- 16.42 versus 556.5 +/- 15.29, P = 0.298). The counts of platelet and eosinophil in the peripheral blood of patients with active tuberculosis are significantly increased as well (289.4 +/- 8.14 versus 248.3 +/- 5.34 [P < 0.0001] and 165.1 +/- 14.33 versus 102.5 +/- 10.72 [P = 0.0005], respectively), and the platelet counts were positively correlated with serum TARC levels (Pearson r = 0.456, P < 0.0001), which indicates a new source of Th2 bias showing in active TB patients.
引用
收藏
页码：629 / 632
页数：4
相关论文
共 29 条
[21]   Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes [J].
Nomiyama, H ;
Hieshima, K ;
Nakayama, T ;
Sakaguchi, T ;
Fujisawa, R ;
Tanase, S ;
Nishiura, H ;
Matsuno, K ;
Takamori, H ;
Tabira, Y ;
Yamamoto, T ;
Miura, R ;
Yoshie, O .
INTERNATIONAL IMMUNOLOGY, 2001, 13 (08) :1021-1029
[22]   Interleukin-13 induces thymus and activation-regulated chemokine (CCL17) in human peripheral blood mononuclear cells [J].
Nomura, T ;
Terada, N ;
Kim, WJ ;
Nakano, K ;
Fukuda, Y ;
Wakita, A ;
Numata, T ;
Konno, A .
CYTOKINE, 2002, 20 (02) :49-55
[23]   T regulatory cells and their counterparts: masters of immune regulation [J].
Ozdemir, C. ;
Akdis, M. ;
Akdis, C. A. .
CLINICAL AND EXPERIMENTAL ALLERGY, 2009, 39 (05) :626-639
[24]   Chemokine expression dynamics in mycobacterial (type-l) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation [J].
Qiu, BQ ;
Frait, KA ;
Reich, F ;
Komuniecki, E ;
Chensue, SW .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (04) :1503-1515
[25]  
SLAWAYA JFD, 2009, CLIN EXP IMMUNOL, V156, P69
[26]   Expression of C-C chemokine TARC in human nasal mucosa and its regulation by cytokines [J].
Terada, N ;
Nomura, T ;
Kim, WJ ;
Otsuka, Y ;
Takahashi, R ;
Kishi, H ;
Yamashita, T ;
Sugawara, N ;
Fukuda, S ;
Ikeda-Ito, T ;
Konno, A .
CLINICAL AND EXPERIMENTAL ALLERGY, 2001, 31 (12) :1923-1931
[27]  
Turken O, 2002, INT J TUBERC LUNG D, V6, P927
[28]   Interleukin-5 mRNA stability in human T cells is regulated differently than interleukin-2, interleukin-3, interleukin-4, granulocyte/macrophage colony-stimulating factor, and interferon-γ [J].
Umland, SP ;
Razac, S ;
Shah, H ;
Nahrebne, DK ;
Egan, RW ;
Billah, MM .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 18 (05) :631-642
[29]   Chemokine Receptor 4 Plays a Key Role in T Cell Recruitment into the Airways of Asthmatic Patients [J].
Vijayanand, Pandurangan ;
Durkin, Kesta ;
Hartmann, Guido ;
Morjaria, Jaymin ;
Seumois, Gregory ;
Staples, Karl J. ;
Hall, David ;
Bessant, Christina ;
Bartholomew, Michelle ;
Howarth, Peter H. ;
Friedmann, Peter S. ;
Djukanovic, Ratko .
JOURNAL OF IMMUNOLOGY, 2010, 184 (08) :4568-4574
123