Antisense inhibition of expression of cysteine proteinases affects Entamoeba histolytica-induced formation of liver abscess in hamsters

被引：108

作者：

Ankri, S ^{[1
]}

Stolarsky, T ^{[1
]}

Bracha, R ^{[1
]}

Padilla-Vaca, F ^{[1
]}

Mirelman, D ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 01期

关键词：

D O I：

10.1128/IAI.67.1.421-422.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Trophozoites of virulent Entamoeba histolytica transfected with the antisense gene encoding cysteine proteinase 5 (CP5) have only 10% of the CP activity but retain their cytopathic activity on mammalian monolayers. In the present study we found that the transfected trophozoites with low levels of CP activity were incapable of inducing the formation of liver lesions in hamsters.

引用

页码：421 / 422

页数：2

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