Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-Å resolution

被引：55

作者：

Kajitani, Kenji ^{[1
]}

Fujihashi, Masahiro ^{[1
]}

Kobayashi, Yukiko ^{[1
]}

Shimizu, Shigeomi ^{[2
,3
]}

Tsujimoto, Yoshihide ^{[2
,3
]}

Miki, Kunio ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan

[2] Osaka Univ, Sch Med, Genet Mol Lab, Dept Med Genet, Suita, Osaka 5650871, Japan

[3] JST, SORST, Suita, Osaka 5650871, Japan

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2008年 / 70卷 / 04期

关键词：

CypD; PPIase (peptidyl-prolyl cis-trans isomerase); CsA; complex preparation; crystal structure;

D O I：

10.1002/prot.21855

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：1635 / 1639

页数：5

共 21 条

[1] THE CCP4 SUITE - PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY [J].

BAILEY, S .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 :760-763

[2] Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death [J].

Baines, CP ;

Kaiser, RA ;

Purcell, NH ;

Blair, NS ;

Osinska, H ;

Hambleton, MA ;

Brunskill, EW ;

Sayen, MR ;

Gottlieb, RA ;

Dorn, GW ;

Robbins, J ;

Molkentin, JD .

NATURE, 2005, 434 (7033) :658-662

[3]

BROEKEMEIER KM, 1989, J BIOL CHEM, V264, P7826

[4] Coot:: model-building tools for molecular graphics [J].

Emsley, P ;

Cowtan, K .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2004, 60 :2126-2132

[5] CYCLOPHILIN AND PEPTIDYL-PROLYL CIS-TRANS ISOMERASE ARE PROBABLY IDENTICAL PROTEINS [J].

FISCHER, G ;

WITTMANNLIEBOLD, B ;

LANG, K ;

KIEFHABER, T ;

SCHMID, FX .

NATURE, 1989, 337 (6206) :476-478

[6] PEPTIDYLPROLINE CIS/TRANS ISOMERASES [J].

GALAT, A ;

METCALFE, SM .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1995, 63 (01) :67-118

[7] Analysis of the cross-reactivity and of the 1.5 Å crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family [J].

Glaser, Andreas G. ;

Limacher, Andreas ;

Flueckiger, Sabine ;

Scheynius, Annika ;

Scapozza, Leonardo ;

Crameri, Reto .

BIOCHEMICAL JOURNAL, 2006, 396 (41-49) :41-49

[8] The permeability transition pore complex: another view [J].

Halestrap, AP ;

McStay, GP ;

Clarke, SJ .

BIOCHIMIE, 2002, 84 (2-3) :153-166

[9] X-RAY STRUCTURE OF A CYCLOPHILIN-B CYCLOSPORINE COMPLEX - COMPARISON WITH CYCLOPHILIN-A AND DELINEATION OF ITS CALCINEURIN-BINDING DOMAIN [J].

MIKOL, V ;

KALLEN, J ;

WALKINSHAW, MD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :5183-5186

[10] X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN-A-CYCLOSPORINE-A CRYSTAL COMPLEX AT 2-CENTER-DOT-1-ANGSTROM RESOLUTION [J].

MIKOL, V ;

KALLEN, J ;

PFLUGL, G ;

WALKINSHAW, MD .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 234 (04) :1119-1130

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