MYCN in Neuroblastoma: "Old Wine into New Wineskins"

被引:18
作者
Braoudaki, Maria [1 ]
Hatziagapiou, Kyriaki [2 ]
Zaravinos, Apostolos [3 ,4 ]
Lambrou, George I. [2 ]
机构
[1] Univ Hertfordshire, Sch Life & Hlth Sci, Dept Life & Environm Sci, Hatfield AL10 9AB, Herts, England
[2] Natl & Kapodistrian Univ Athens, Dept Pediat 1, Choremeio Res Lab, Thivon & Levadeias 8, Athens 11527, Greece
[3] European Univ Cyprus, Dept Life Sci, Diogenis Str 6, CY-2404 Nicosia, Cyprus
[4] European Univ Cyprus, Basic & Translat Canc Res Ctr, Canc Genet Genom & Syst Biol Grp, CY-1516 Nicosia, Cyprus
关键词
MYCN; amplification; epigenetic regulation; acetylation; G-quadraplex; neuroblastoma; MICRORNA TARGET PREDICTION; COMPARATIVE-GENOMIC-HYBRIDIZATION; HIGH-RESOLUTION ANALYSIS; TUMOR-SUPPRESSOR GENES; N-MYC; PROGNOSTIC-SIGNIFICANCE; G-QUADRUPLEX; AMPLIFIED NEUROBLASTOMA; ABERRANT METHYLATION; CELL-DEATH;
D O I
10.3390/diseases9040078
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent targets for neuroblastoma therapy. In the present work, we attempted to review the literature, on the relation between MYCN and neuroblastoma from all possible mechanistic sites. We have searched the literature for the role of MYCN in neuroblastoma based on the following topics: the references of MYCN in the literature, the gene's anatomy, along with its transcripts, the protein's anatomy, the epigenetic mechanisms regulating MYCN expression and function, as well as MYCN amplification. MYCN plays a significant role in neuroblastoma biology. Its functions and properties range from the forming of G-quadraplexes, to the interaction with miRNAs, as well as the regulation of gene methylation and histone acetylation and deacetylation. Although MYCN is one of the most primary genes studied in neuroblastoma, there is still a lot to be learned. Our knowledge on the exact mechanisms of MYCN amplification, etiology and potential interventions is still limited. The knowledge on the molecular mechanisms of MYCN in neuroblastoma, could have potential prognostic and therapeutic advantages.
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页数:39
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