Pathogenesis of Mucous Membrane Pemphigoid

被引：16
作者：
Kourosh, A. Shadi [1 ]
Yancey, Kim B. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Dermatol, Dallas, TX 75390 USA
来源：
DERMATOLOGIC CLINICS | 2011年 / 29卷 / 03期
关键词：
Mucous membrane; Pemphigoid; Autoimmune; Pathogenesis; EPIDERMOLYSIS-BULLOSA ACQUISITA; INDUCE SUBEPIDERMAL BLISTERS; PASSIVE TRANSFER; NEONATAL MICE; VII-COLLAGEN; ANTIBODIES; DISEASE; AUTOANTIBODIES; AUTOIMMUNE; SEPARATION;
D O I：
10.1016/j.det.2011.03.011
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Mucous membrane pemphigoid (M MP) is the clinical phenotype of a group of autoimmune blistering diseases characterized by autoantibodies directed against different structural proteins in epidermal basement membranes. The clinical course and prognosis of MMP are affected by the specific autoantigen targeted, the titer and bioactivity profile of corresponding autoantibodies, and the specific mucosal sites of disease activity. Irreversible scarring and loss of function must be prevented by early diagnosis and appropriate interventions.
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收藏
页码：479 / +
页数：7
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