Extracts and constituents of Lavandula multifida with topical anti-inflammatory activity

被引：74
作者：
Sosa, S
Altinier, G
Politi, M
Braca, A
Morelli, I
Della Loggia, R
机构：
[1] Univ Trieste, Dipartimento Econ & Merceol, I-34127 Trieste, Italy
[2] Univ Pisa, Dipartimento Chim Bioorgan & Biofarmacia, I-56126 Pisa, Italy
来源：
PHYTOMEDICINE | 2005年 / 12卷 / 04期
关键词：
Lavandula multifida; Lamiaceae; anti-inflammatory activity; terpenoids; croton oil ear test;
D O I：
10.1016/j.phymed.2004.02.007
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The topical anti-inflammatory activity of the ethanol and aqueous extracts from the aerial parts of Lavandula multifida L. (Lamiaceae), used in the Moroccan traditional medicine, was investigated by inhibition of the Croton oil-induced ear edema in mice. The biological assay revealed a dose-dependent anti-inflammatory activity for the ethanol extract, while the aqueous one was less active. Bioassay-guided fractionation of the ethanol extract led to identify four triterpenic acids of oleanane series, four pimarane and one iso-pimarane diterpenes, as well as the phenolic monoterpene carvacrol and its glucoside. Some of these compounds revealed an anti-inflammatory activity comparable to that of indomethacin. (c) 2004 Published by Elsevier GmbH.
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收藏
页码：271 / 277
页数：7
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