Preparation and Characterization of Ginger Peel Polysaccharide-Zn (II) Complexes and Evaluation of Anti-Inflammatory Activity

被引：14

作者：

Li, Wenwen ^{[1
]}

Qiu, Zhichang ^{[1
]}

Ma, Yue ^{[2
]}

Zhang, Bin ^{[1
]}

Li, Lingyu ^{[1
]}

Li, Qiulin ^{[3
]}

He, Qiuxia ^{[4
]}

Zheng, Zhenjia ^{[1
]}

机构：

[1] Shandong Agr Univ, Shandong Higher Educ Inst, Coll Food Sci & Engn, Key Lab Food Proc Technol & Qual Control, Tai An 271018, Peoples R China

[2] Beijing Acad Agr & Forestry Sci, Inst Agrifood Proc & Nutr, Beijing Key Lab Agr Prod Fruits & Vegetables Prese, Key Lab Vegetable Postharvest Proc,Minist Agr & Ru, Beijing 100097, Peoples R China

[3] Suzhou Univ Sci & Technol, Sch Mat Sci & Engn, Suzhou 215011, Peoples R China

[4] Qilu Univ Technol, Shandong Acad Sci, Sci & Technol Serv Platform Shandong Acad Sci, Jinan 250103, Peoples R China

来源：

ANTIOXIDANTS | 2022年 / 11卷 / 12期

关键词：

ginger peel polysaccharide-Zn (II) complexes; synthesis; structural characterization; anti-inflammatory activity; zebrafish; STRUCTURAL-CHARACTERIZATION; NEUTRAL POLYSACCHARIDE; PATHWAYS; EXERTS;

D O I：

10.3390/antiox11122331

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study aimed to explore the improvement of the bioactivity of ginger peel polysaccharides (GPs) by the modification of zinc after structural characterization. The obtained GP-Zn (II) complexes consisted dominantly of glucose and galactose in a mass proportion of 95.10:2.10, with a molecular weight of 4.90 x 10(5) Da and a Zn content of 21.17 mg/g. The chelation of GPs and Zn (II) was mainly involved in the O-H of hydroxyl groups, and this interaction reduced the crystallinity and decreased the asymmetry of GPs, with a slight effect on the thermal stability. The administration of GPs and their Zn (II) complexes effectively alleviated CuSO4-induced inflammatory response in zebrafish (Tg: zlyz-EGFP) via down-regulating the mRNA expression levels of pro-inflammatory cytokines (IL-1 beta, IL-6, IL-8, IL-12 and TNF-alpha) and upregulating the expression of anti-inflammatory cytokine (IL-10). Furthermore, the modification of Zn (II) enhanced the inflammation-inhibiting effect of polysaccharides. Therefore, GP-Zn (II) complexes could be applied as a candidate anti-inflammatory agent for the treatment of chronic inflammation-related diseases.

引用

页数：16

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