Dietary daidzein decreases food intake accompanied with delayed gastric emptying in ovariectomized rats

被引：2

作者：

Adhikari, Sudhashree ^{[1
]}

Bhattarai, Keshab ^{[1
]}

Abe, Yasuhiro ^{[2
]}

Kira, Mayu ^{[2
]}

Fujitani, Mina ^{[2
]}

Miyada, Tomihiro ^{[3
]}

Kishida, Taro ^{[1
,2
]}

机构：

[1] Ehime Univ, United Grad Sch Agr Sci, Matsuyama, Ehime, Japan

[2] Ehime Univ, Grad Sch Agr, Matsuyama, Ehime, Japan

[3] Kawasaki Univ Med Welf, Fac Hlth Sci & Technol, Dept Clin Nutr, Kurashiki, Okayama, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2020年 / 84卷 / 06期

基金：

日本学术振兴会;

关键词：

Daidzein; anorectic effect; gastric emptying; ESTROGEN-RECEPTOR-BETA; FEMALE RATS; ISOFLAVONE INTAKE; CENTRAL CRF; S-EQUOL; ACCUMULATION; SATIETY; VOLUME; MEAL; FAT;

D O I：

10.1080/09168451.2020.1723404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously found that equol, a metabolite of intestinal bacterial conversion from soy isoflavone daidzein, has female-specific anorectic effects. In the present study, we used seven-week-old female ovariectomized (OVX) Sprague Dawley rats to test the hypothesis that the anorectic effect of dietary daidzein may be attributed to delayed gastric emptying. Results suggest that dietary daidzein delays gastric emptying and that it has an anorectic effect with residual gastric contents, but not without gastric contents. Dietary equol significantly decreased daily food intake in the OVX rats without sleeve gastrectomy, but not in those with sleeve gastrectomy, suggesting that the accumulation of food in the stomach is required for the anorectic effect of equol to occur. These results support the hypothesis that the anorectic effect of dietary daidzein is attributed to delayed gastric emptying.

引用

页码：1232 / 1238

页数：7

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