Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials

被引：133

作者：

Derosa, Giuseppe ^{[1
,2
,3
,4
,5
]}

Maffioli, Pamela ^{[1
,2
,6
]}

Simental-Mendia, Luis E. ^{[7
]}

Bo, Simona ^{[8
]}

Sahebkar, Amirhossein ^{[9
]}

机构：

[1] Univ Pavia, Ctr Diabet & Metab Dis, Dept Internal Med & Therapeut, Pavia, Italy

[2] Fdn IRCCS Policlin S Matteo, Pavia, Italy

[3] Univ Pavia, Ctr Study Endocrine Metab Pathophysiol & Clin Res, Pavia, Italy

[4] Fdn IRCCS Policlin S Matteo, Ctr Prevent Surveillance Diag & Treatment Rare Di, Pavia, Italy

[5] Univ Pavia, Mol Med Lab, Pavia, Italy

[6] Univ Pavia, PhD Sch Expt Med, Pavia, Italy

[7] Mexican Social Secur Inst, Biomed Res Unit, Durango, Mexico

[8] Univ Turin, Dept Med Sci, Turin, Italy

[9] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran

来源：

PHARMACOLOGICAL RESEARCH | 2016年 / 111卷

关键词：

Curcuma longa; Curcumin; Inflammation; Meta-analysis; Interleukin-6; C-REACTIVE PROTEIN; QUALITY-OF-LIFE; DOUBLE-BLIND; TNF-ALPHA; KNEE OSTEOARTHRITIS; CLINICAL-PRACTICE; OXIDATIVE STRESS; INFLAMMATION; PLACEBO; SUPPLEMENTATION;

D O I：

10.1016/j.phrs.2016.07.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this meta-analysis was to evaluate the efficacy of curcuminoids supplementation on circulating concentrations of IL-6 in randomized controlled trials (RCTs). The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to November 01, 2015, to identify RCTs investigating the impact of curcuminoids on circulating IL-6 concentrations. Nine RCTs comprising 10 treatment arms were found to be eligible for the meta-analysis. There was a significant reduction of circulating IL-6 concentrations following curcuminoids supplementation (WMD: -0.60 pg/mL, 95% CI: -1.06, -0.14, p = 0.011). Meta-regression did not suggest any significant association between the circulating IL-6 lowering effects of curcuminoids with either dose or duration of treatment. There was a significant association between the IL-6-lowering activity of curcumin and baseline IL-6 concentration (slope: -0.51; 95% CI: -0.80, -0.23; p = 0.005). This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating IL-6 concentrations. This effect appears to be more evident in patients with higher degrees of systemic inflammation. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：394 / 404

页数：11

共 64 条

[31] Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin [J].

Ikonomidis, I ;

Andreotti, F ;

Economou, E ;

Stefanadis, C ;

Toutouzas, P ;

Nihoyannopoulos, P .

CIRCULATION, 1999, 100 (08) :793-798

[32] Therapeutic uses of anti-interleukin-6 receptor antibody [J].

Kang, Sujin ;

Tanaka, Toshio ;

Kishimoto, Tadamitsu .

INTERNATIONAL IMMUNOLOGY, 2015, 27 (01) :21-29

[33] Curcumin half analog modulates interleukin-6 and tumor necrosis factor-alpha in inflammatory bowel disease [J].

Kondamudi, Phani Krishna ;

Kovelamudi, Hemalatha ;

Nayak, Pawan G. ;

Rao, Mallikarjuna Chamallamudi ;

Shenoy, Rekha Raghuveer .

PHARMACOGNOSY MAGAZINE, 2015, 11 (44) :S296-S302

[34] Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling [J].

Miao, Yanping ;

Zhao, Sheng ;

Gao, Yang ;

Wang, Ruijun ;

Wu, Qiong ;

Wu, Hui ;

Luo, Tianyou .

BRAIN RESEARCH BULLETIN, 2016, 121 :9-15

[35] Effects of Supplementation with Curcuminoids on Dyslipidemia in Obese Patients: A Randomized Crossover Trial [J].

Mohammadi, Akram ;

Sahebkar, Amirhossein ;

Iranshahi, Mehrdad ;

Amini, Maral ;

Khojasteh, Roshanak ;

Ghayour-Mobarhan, Majid ;

Ferns, Gordon A. .

PHYTOTHERAPY RESEARCH, 2013, 27 (03) :374-379

[36]

Moher D, 2015, SYST REV-LONDON, V4, DOI [10.1186/2046-4053-4-1, 10.1136/bmj.i4086, 10.1016/j.ijsu.2010.07.299, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1136/bmj.b2535, 10.1016/j.ijsu.2010.02.007]

[37] Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes [J].