Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials

被引:133
作者
Derosa, Giuseppe [1 ,2 ,3 ,4 ,5 ]
Maffioli, Pamela [1 ,2 ,6 ]
Simental-Mendia, Luis E. [7 ]
Bo, Simona [8 ]
Sahebkar, Amirhossein [9 ]
机构
[1] Univ Pavia, Ctr Diabet & Metab Dis, Dept Internal Med & Therapeut, Pavia, Italy
[2] Fdn IRCCS Policlin S Matteo, Pavia, Italy
[3] Univ Pavia, Ctr Study Endocrine Metab Pathophysiol & Clin Res, Pavia, Italy
[4] Fdn IRCCS Policlin S Matteo, Ctr Prevent Surveillance Diag & Treatment Rare Di, Pavia, Italy
[5] Univ Pavia, Mol Med Lab, Pavia, Italy
[6] Univ Pavia, PhD Sch Expt Med, Pavia, Italy
[7] Mexican Social Secur Inst, Biomed Res Unit, Durango, Mexico
[8] Univ Turin, Dept Med Sci, Turin, Italy
[9] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran
关键词
Curcuma longa; Curcumin; Inflammation; Meta-analysis; Interleukin-6; C-REACTIVE PROTEIN; QUALITY-OF-LIFE; DOUBLE-BLIND; TNF-ALPHA; KNEE OSTEOARTHRITIS; CLINICAL-PRACTICE; OXIDATIVE STRESS; INFLAMMATION; PLACEBO; SUPPLEMENTATION;
D O I
10.1016/j.phrs.2016.07.004
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The aim of this meta-analysis was to evaluate the efficacy of curcuminoids supplementation on circulating concentrations of IL-6 in randomized controlled trials (RCTs). The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to November 01, 2015, to identify RCTs investigating the impact of curcuminoids on circulating IL-6 concentrations. Nine RCTs comprising 10 treatment arms were found to be eligible for the meta-analysis. There was a significant reduction of circulating IL-6 concentrations following curcuminoids supplementation (WMD: -0.60 pg/mL, 95% CI: -1.06, -0.14, p = 0.011). Meta-regression did not suggest any significant association between the circulating IL-6 lowering effects of curcuminoids with either dose or duration of treatment. There was a significant association between the IL-6-lowering activity of curcumin and baseline IL-6 concentration (slope: -0.51; 95% CI: -0.80, -0.23; p = 0.005). This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating IL-6 concentrations. This effect appears to be more evident in patients with higher degrees of systemic inflammation. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:394 / 404
页数:11
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