Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome

被引：7

作者：

Hashimoto, Miki ^{[1
]}

Itonaga, Hidehiro ^{[2
]}

Nannya, Yasuhito ^{[3
]}

Taniguchi, Hirokazu ^{[4
]}

Fukuda, Yuichi ^{[5
]}

Furumoto, Takafumi ^{[6
]}

Fujioka, Machiko ^{[1
,7
]}

Kasai, Sachie ^{[1
]}

Taguchi, Masataka ^{[7
]}

Taniguchi, Hiroaki ^{[6
]}

Sato, Shinya ^{[7
]}

Sawayama, Yasushi ^{[7
]}

Atogami, Sunao ^{[8
]}

Iwasaki, Keisuke ^{[9
]}

Hata, Tomoko ^{[2
]}

Soda, Hiroshi ^{[5
]}

Moriuchi, Yukiyoshi ^{[6
]}

Nakata, Koh ^{[10
]}

Ogawa, Seishi ^{[3
]}

Miyazaki, Yasushi ^{[1
,2
,7
]}

机构：

[1] Nagasaki Univ, Dept Hematol, Grad Sch Biomed Sci, Nagasaki, Japan

[2] Nagasaki Univ, Atom Bomb Dis Inst, Dept Hematol, Atom Bomb Dis & Hibakusha Med Unit, Nagasaki, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Pathol & Tumor Biol, Kyoto, Japan

[4] Nagasaki Univ, Dept Resp Med, Grad Sch Biomed Sci, Nagasaki, Japan

[5] Sasebo City Gen Hosp, Dept Resp Med, Nagasaki, Japan

[6] Sasebo City Gen Hosp, Dept Hematol, Nagasaki, Japan

[7] Nagasaki Univ Hosp, Dept Hematol, Nagasaki, Japan

[8] Sasebo City Gen Hosp, Dept Clin Lab, Nagasaki, Japan

[9] Sasebo City Gen Hosp, Dept Pathol, Nagasaki, Japan

[10] Niigata Univ Med & Dent Hosp, Biosci Med Res Ctr, Niigata, Japan

来源：

INTERNAL MEDICINE | 2020年 / 59卷 / 08期

基金：

日本学术振兴会;

关键词：

myelodysplastic syndromes; secondary pulmonary alveolar proteinosis; azacitidine; umbilical cord blood transplantation; PROGNOSTIC SCORING SYSTEM; CELL TRANSPLANTATION; DNA METHYLATION; DISEASE; NEOPLASMS; SURVIVAL; REGIMENS;

D O I：

10.2169/internalmedicine.3770-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Secondary pulmonary alveolar proteinosis (sPAP) is a complication of myelodysplastic syndrome (MDS). A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a bone marrow examination revealed increased myeloblasts, at which time computed tomography showed diffuse ground-glass opacities and interlobular septal thickening in the bilateral lower lung fields. A lung biopsy revealed the presence of PAP; therefore, the clinical diagnosis of MDS/sPAP was confirmed. Careful attention should be paid to the development of sPAP in MDS patients with pulmonary lesions during azacitidine treatment.

引用

页码：1081 / 1086

页数：6

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