Atom Economy in the Metathesis Cross-Coupling of Alkenes and Alkynes

被引：22

作者：

Clark, Joseph R. ^{[1
]}

Diver, Steven T. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Amherst, NY 14260 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 11期

基金：

美国国家科学基金会;

关键词：

RUTHENIUM CARBENE COMPLEXES; OLEFIN METATHESIS; ENYNE METATHESIS; TANDEM CATALYSIS; ISOMERIZATION; EFFICIENCY; MECHANISM; PHOSPHINE;

D O I：

10.1021/ol200914j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cross ene-yne metathesis has been achieved at a nearly 1:1 stoichiometry of the unsaturated reactants. This allowed the use of more complex alkene reactants without sacrificing excess alkene reactant. In the alkene, different allylic oxygen protecting groups were explored. Interestingly, alkenes containing the allylic hydroxyl group proved to be the most reactive.

引用

页码：2896 / 2899

页数：4

共 25 条

[21] New tandem catalysis: Preparation of cyclic enol ethers through a ruthenium-catalyzed ring-closing metathesis-olefin isomerization sequence [J].