Complete pathological response to neoadjuvant treatment is associated with better survival outcomes in patients with soft tissue sarcoma: Results of a retrospective multicenter study

被引：41

作者：

Bonvalot, Sylvie ^{[1
]}

Wunder, Jay ^{[2
]}

Gronchi, Alessandro ^{[3
]}

Broto, Javier Martin ^{[4
,5
]}

Turcotte, Robert ^{[6
]}

Rastrelli, Marco ^{[7
]}

Papai, Zsuzsanna ^{[8
]}

Radaelli, Stefano ^{[3
]}

Lindner, Lars H. ^{[9
]}

Shumelinsky, Felix ^{[10
]}

Cubillo, Antonio ^{[11
]}

Rutkowski, Piotr ^{[12
]}

Demaire, Clementine ^{[13
]}

Strens, Danielle ^{[13
]}

Nalbantov, Georgi ^{[13
]}

机构：

[1] Paris Univ, Inst Curie, Dept Surg, Paris, France

[2] Sinai Hlth Syst, Dept Surg, Toronto, ON, Canada

[3] Fdn IRCCS Ist Nazl Tumori, Dept Surg, Milan, Italy

[4] Univ Seville, Dept Med Oncol, Hosp Virgen Del Rocio, CSIC, Seville, Spain

[5] Univ Seville, Inst Biomed Sevilla IBIS HUVR, CSIC, Seville, Spain

[6] McGill Univ Hlth Ctr, Dept Surg, Montreal, PQ, Canada

[7] Ist Oncol Veneto, Dept Surg Oncol, Padua, Italy

[8] Hungarian Def Forces Mil Hosp, Honved Hosp, Dept Oncol, Budapest, Hungary

[9] Ludwig Maximilians Univ Munchen, Dept Med 3, Univ Hosp, Munich, Germany

[10] Jules Bordet Inst, Dept Surg Bone & Connect Tissue Tumour Surg, Brussels, Belgium

[11] Hosp Univ Sanchinarro, Ctr Integral Oncol Clara Campal HM CIOCC, Dept Med Oncol, Madrid, Spain

[12] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Soft Tissue Bone Sarcoma & Melanoma, Warsaw, Poland

[13] Monitor Deloitte, Hlth Econ & Outcome Res Team, Zaventem, Belgium

来源：

EJSO | 2021年 / 47卷 / 08期

关键词：

Sarcoma; Surgery; Preoperative treatment; Pathological response; Survival outcomes; Retrospective study; EUROPEAN ORGANIZATION; EXTERNAL VALIDATION; DISTANT METASTASES; RADIATION-THERAPY; CHEMOTHERAPY; EXTREMITY; NECROSIS; SURGERY; RADIOTHERAPY; NOMOGRAMS;

D O I：

10.1016/j.ejso.2021.02.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Locally advanced soft tissue sarcoma (STS) management may include neoadjuvant or adjuvant treatment by radiotherapy (RT), chemotherapy (CT) or chemoradiotherapy (CRT) followed by wide surgical excision. While pathological complete response (pCR) to preoperative treatment is prognostic for survival in osteosarcomas, its significance for STS is unclear. We aimed to evaluate the prognostic significance of pCR to pre-operative treatment on 3-year disease-free survival (3y-DFS) in STS patients. Methods: This is an observational, retrospective, international, study of adult patients with primary non-metastatic STS of the extremities and trunk wall, any grade, diagnosed between 2008 and 2012, treated with at least neoadjuvant treatment and surgical resection and observed for a minimum of 3 years after diagnosis. The primary objective was to evaluate the effect of pCR. (<= 5% viable tumor cells or >= 95% necrosis/fibrosis) on 3y-DFS. Effect on local recurrence-free survival (LRFS), distant recurrence-free survival (MFS) overall survival (OS) at 3 years was also analyzed. Statistical univariate analysis utilized chi-square independence test and odds ratio confidence interval (CI) estimate, multivariate analysis was performed using LASSO. Results: A total of 330 patients (median age 56 years old, range:19-95) treated by preoperative RT (67%), CT (15%) or CRT (18%) followed by surgery were included. pCR was achieved in 74/330 (22%) of patients, of which 56/74 (76%) had received RT. 3-yr DFS was observed in 76% of patients with pCR vs 61% without pCR (p < 0.001). Multivariate analysis showed that pCR is statistically associated with better MFS (95% CI, 1.054-3.417; p = 0.033), LRFS (95% CI, 1.226-5.916; p = 0.014), DFS (95% CI, 1.165-4.040; p = 0.015) and OS at 3 years (95% CI, 1.072-5.210; p = 0.033). Conclusions: In a wide, heterogeneous STS population we showed that pCR to preoperative treatment is prognostic for survival. (C) 2021 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

引用

页码：2166 / 2172

页数：7

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