Mimicking DNA Functions with Abiotic, Sequence-Defined Polymers

被引：6

作者：

Leguizamon, Samuel C. ^{[1
]}

Scott, Timothy F. ^{[2
,3
]}

机构：

[1] Univ Michigan, Dept Chem Engn, Ann Arbor, MI USA

[2] Monash Univ, Dept Chem Engn, Clayton, Vic 3800, Australia

[3] Monash Univ, Dept Mat Sci & Engn, Clayton, Vic, Australia

来源：

POLYMER REVIEWS | 2022年 / 62卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Sequence-defined polymers; DNA mimicry; molecular ladder; synthetic polymer; templating; replication; DOUBLE HELICES; NEXT-GENERATION; INFORMATION-STORAGE; SYNTHETIC-POLYMERS; SELF-REPLICATION; OLIGOMERS; RECOGNITION; VERNIER; POLYMERIZATION; PEPTIDE;

D O I：

10.1080/15583724.2021.2014519

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Advances in synthetic chemistry have enabled abiotic, sequence defined polymers to imitate the structures and functions once exclusive to DNA. Indeed, the vast library of accessible backbones and pendant-group functionalities afford synthetic polymers an advantage over DNA in emerging applications as they can be tailored for stability or performance. Moreover, novel methodologies for sequencing and conjugation have been leveraged to elevate the versatility of discrete macromolecules. This review highlights abiotic, sequence-defined polymers in their capacity to mimic the primary functions of DNA - data storage and retrieval, sequence-specific self-assembly of duplexes, and replication and synthetic templating of new macromolecules.

引用

页码：626 / 651

页数：26

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