PET/CT comparing 68Ga-DOTATATE and other radiopharmaceuticals and in comparison with CT/MRI for the localization of sporadic metastatic pheochromocytoma and paraganglioma

被引：124

作者：

Janssen, Ingo ^{[1
,2
]}

Chen, Clara C. ^{[3
]}

Millo, Corina M. ^{[4
]}

Ling, Alexander ^{[5
]}

Taieb, David ^{[6
]}

Lin, Frank I. ^{[7
]}

Adams, Karen T. ^{[1
]}

Wolf, Katherine I. ^{[1
]}

Herscovitch, Peter ^{[4
]}

Fojo, Antonio T. ^{[8
]}

Buchmann, Inga ^{[2
]}

Kebebew, Electron ^{[9
]}

Pacak, Karel ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Adult & Reprod Endocrinol, NIH, Bldg 10,CRC,Room 1E-3140,10 Ctr Dr MSC 1109, Bethesda, MD 20892 USA

[2] Univ Hosp Schleswig Holstein, Nucl Med Sect, Dept Radiol & Nucl Med, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany

[3] NIH, Nucl Med Div Radiol & Imaging Sci, Ctr Clin, Bethesda, MD 20892 USA

[4] NIH, Positron Emiss Tomog Dept, Ctr Clin, Bethesda, MD 20892 USA

[5] NIH, Radiol & Imaging Sci, Ctr Clin, Bethesda, MD 20892 USA

[6] Aix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, CERIMED, Marseille, France

[7] NCI, Canc Imaging Program, NIH, Bethesda, MD 20892 USA

[8] NCI, Endocrine Oncol Branch, Bethesda, MD 20892 USA

[9] NCI, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2016年 / 43卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Ga-68-DOTATATE; F-18-FDG; Pheochromocytoma; Paraganglioma; Metastatic; POSITRON-EMISSION-TOMOGRAPHY; I-123-MIBG SPECT; TUMORS; SDHB; DIAGNOSIS; CANCER; HEAD; NEUROENDOCRINE; METAANALYSIS; SUPERIORITY;

D O I：

10.1007/s00259-016-3357-x

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Pheochromocytomas/paragangliomas (PPGLs) and their metastases are tumors that predominantly express somatostatin receptor 2 (SSR2). Ga-68-DOTA(0)-Tyr(3)-octreotate (Ga-68-DOTATATE) is a PET radiopharmaceutical with both high and selective affinity for SSRs. The purpose of this study was to evaluate the utility of Ga-68-DOTATATE in comparison with other specific and nonspecific radiopharmaceuticals recommended in the current guidelines for the localization of metastatic sporadic PPGL by PET/CT. This prospective study included 22 patients (15 men, 7 women; aged 50.0 +/- 13.9 years) with confirmed metastatic PPGL, a negative family history for PPGL, and negative genetic testing, who underwent Ga-68-DOTATATE, F-18-fluoro-2-deoxy-D-glucose (F-18-FDG) PET/CT, and CT/MRI. Only 12 patients underwent an additional F-18-fluorodihydroxyphenylalanine (F-18-FDOPA) PET/CT scan and only 11 patients underwent an additional F-18-fluorodopamine (F-18-FDA) PET/CT scan. The rates of detection of metastatic lesions were compared among all the imaging studies. A composite of all functional and anatomical imaging studies served as the imaging comparator. Ga-68-DOTATATE PET/CT showed a lesion-based detection rate of 97.6 % (95 % confidence interval, CI, 95.8 - 98.7 %). F-18-FDG PET/CT, F-18-FDOPA PET/CT, F-18-FDA PET/CT, and CT/MRI showed detection rates of 49.2 % (CI 44.5 - 53.6 %; p < 0.01), 74.8 % (CI 69.0 - 79.9 %); p < 0.01), 77.7 % (CI 71.5 - 82.8 %; p < 0.01), and 81.6 % (CI 77.8 - 84.8 %; p < 0.01), respectively. The results of this study demonstrate the superiority of Ga-68-DOTATATE PET/CT in the localization of sporadic metastatic PPGLs compared to all other functional and anatomical imaging modalities, and suggest modification of future guidelines towards this new imaging modality.

引用

页码：1784 / 1791

页数：8

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