Sequential copper-catalyzed vinylation/cyclization: An efficient synthesis of functionalized oxazoles

被引：134
|
作者：
Martin, Rubn [1 ]
Cuenca, Ana [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 26期
关键词：
D O I：
10.1021/ol7024718
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A modular and practical synthesis of highly substituted oxazoles has been developed. The transformation consists of a sequential copper-catalyzed amidation of vinyl halides followed by cyclization promoted by iodine. A wide variety of functionalized oxazoles and polyazoles can be obtained in a selective manner from simple and easily accessible precursors.
引用
收藏
页码：5521 / 5524
页数：4
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