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Sequential copper-catalyzed vinylation/cyclization: An efficient synthesis of functionalized oxazoles
被引:134
作者:
Martin, Rubn
[1
]
Cuenca, Ana
[1
]
Buchwald, Stephen L.
[1
]
机构:
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
关键词:
D O I:
10.1021/ol7024718
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
A modular and practical synthesis of highly substituted oxazoles has been developed. The transformation consists of a sequential copper-catalyzed amidation of vinyl halides followed by cyclization promoted by iodine. A wide variety of functionalized oxazoles and polyazoles can be obtained in a selective manner from simple and easily accessible precursors.
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页码:5521 / 5524
页数:4
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