Synthesis, Characterization, DNA Binding Properties, and Antioxidant Activity of Novel Copper(II) and Zinc(II) Complexes with Bis(pyrrol-2-yl-methylamine) Ligands

被引：8

作者：

Li, Yong ^{[1
,2
]}

Yang, Zheng-Yin ^{[1
,2
]}

Wang, Yuan ^{[1
,2
,3
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Henan Polytech Univ, Dept Chem & Phys, Jiaozuo 454003, Peoples R China

来源：

ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE | 2011年 / 637卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Copper; Zinc; DNA binding properties; Viscosity measurements; Antioxidants; RUTHENIUM(II) COMPLEXES; BIOLOGICAL-ACTIVITY; METAL-COMPLEXES; IN-VITRO; FLUORESCENCE; SUPEROXIDE; COBALT(II); AGENTS;

D O I：

10.1002/zaac.201000199

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three novel ligands H4Ln (n = 1-3) and their copper(II) and zinc(II) complexes were prepared and characterized on the basis of elemental analyses, molar conductivity, H-1 NMR, UV/Vis, and IR spectroscopy as well as mass spectrometry. DNA binding properties of the ligands and their complexes were investigated by absorption spectroscopy, ethidium bromide displacement experiments, and viscosity measurements. The experimental results indicate that the new ligands and their complexes can bind to DNA and the binding affinities of the complexes are higher than those of the ligands. In addition, the antioxidant activity of the ligands and complexes was determined by superoxide and hydroxyl radical scavenging methods in vitro, indicating that the complexes exhibit more effective antioxidant activity than the ligands alone.

引用

页码：323 / 330

页数：8

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