Abnormal DNA content in oral epithelial dysplasia is associated with increased risk of progression to carcinoma

被引：64
作者：
Bradley, G. [1 ,2 ]
Odell, E. W. [3 ]
Raphael, S. [4 ]
Ho, J. [5 ]
Le, L. W. [6 ]
Benchimol, S. [7 ]
Kamel-Reid, S. [2 ,8 ]
机构：
[1] Univ Toronto, Fac Dent, Toronto, ON M5G 1G6, Canada
[2] Univ Toronto, Univ Hlth Network, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
[3] Kings Coll London, Dept Oral Pathol, Guys Hosp, London SE1 9RT, England
[4] Univ Toronto, Dept Pathol, Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3N5, Canada
[5] Univ Toronto, Ontario Canc Inst, Appl Mol Profiling Lab, Toronto, ON, Canada
[6] Univ Hlth Network, Dept Biostat, Toronto, ON, Canada
[7] York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada
[8] Univ Hlth Network, Dept Pathol, Toronto, ON, Canada
来源：
BRITISH JOURNAL OF CANCER | 2010年 / 103卷 / 09期
关键词：
DNA cytometry; oral; epithelial dysplasia; carcinoma; SQUAMOUS-CELL CARCINOMA; PREDICT MALIGNANT RISK; PREMALIGNANT LESIONS; BARRETTS-ESOPHAGUS; IMAGE CYTOMETRY; NECK-CANCER; TRANSFORMATION; TETRAPLOIDY; LEUKOPLAKIA; INSTABILITY;
D O I：
10.1038/sj.bjc.6605905
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Oral epithelial dysplasia (OED) is a histologically detectable lesion that may progress to carcinoma but there are no accurate markers that predict progression. This study examined the development of carcinoma from oral dysplastic lesions, and the association between abnormal DNA content and progression to carcinoma. METHODS: Epithelial dysplasias from the Oral Pathology Diagnostic Service were matched against the Ontario Cancer Registry database to identify cases that progressed to carcinoma. A case-control study was conducted to compare DNA image cytometry of dysplasias that progressed with those that have not progressed. For a subset of the progressed dysplasias, DNA content of the carcinoma was also analysed. RESULTS: A total of 8% of epithelial dysplasias progressed to carcinoma after 6-131 months. In all, 28 of 99 dysplasias showed abnormal DNA content by image cytometry. In multivariate analysis of time to progression, abnormal DNA content was a significant predictor with hazard ratio of 3.3 (95% confidence interval: 1.5-7.4) corrected for site and grade of dysplasia. Analysis of sequential samples of dysplasia and carcinoma suggested that epithelial cell populations with grossly abnormal DNA content were transient intermediates during oral cancer development. CONCLUSIONS: Abnormal DNA content is a significant biomarker of a subset of OED that progress to carcinoma. British Journal of Cancer (2010) 103, 1432-1442. doi: 10.1038/sj.bjc.6605905 www.bjcancer.com Published online 21 September 2010 (C) 2010 Cancer Research UK
引用
收藏
页码：1432 / 1442
页数：11
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