Methylphenidate Alters Functional Connectivity of Default Mode Network in Drug-Naive Male Adults With ADHD

被引：20

作者：

Picon, Felipe Almeida ^{[1
,2
,3
]}

Sato, Joao Ricardo ^{[3
,4
]}

Anes, Mauricio ^{[1
,2
]}

Vedolin, Leonardo Modesti ^{[5
]}

Mazzola, Alessandro Andre ^{[6
]}

Valentini, Bruna Bressan ^{[7
]}

Cupertino, Renata Basso ^{[1
,8
]}

Karam, Rafael Gomes ^{[1
]}

Victor, Marcelo Moraes ^{[1
,2
]}

Breda, Vitor ^{[1
,2
]}

Silva, Katiane ^{[1
,2
]}

da Silva, Neivo, Jr. ^{[9
]}

Bau, Claiton Henrique Dotto ^{[1
,2
,8
]}

Grevet, Eugenio Horacio ^{[1
,2
]}

Rohde, Luis Augusto Paim ^{[1
,2
,3
]}

机构：

[1] Hosp Clin Porto Alegre, ADHD Outpatient Program, Adult Div, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil

[3] CNPq, Natl Inst Dev Psychiat Children & Adolescents, Brasilia, DF, Brazil

[4] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre, SP, Brazil

[5] Grp DASA, Sao Paulo, Brazil

[6] PhyMED Med Phys & Radioprotect Consulting, Porto Alegre, RS, Brazil

[7] Hosp Moinhos Vento, Porto Alegre, RS, Brazil

[8] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS, Brazil

[9] Santa Casa Misericordia, Nucl Med Lab, Hosp Santa Rita, Porto Alegre, RS, Brazil

来源：

JOURNAL OF ATTENTION DISORDERS | 2020年 / 24卷 / 03期

关键词：

ADHD; MPH; fMRI; resting-state functional connectivity; intrinsic connectivity; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; GRAY-MATTER; HUMAN BRAIN; ARCHITECTURE; CORTEX; DEFICITS; ANATOMY; SYSTEMS;

D O I：

10.1177/1087054718816822

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective: This study evaluated the hypothesis that methylphenidate immediate release (MPH-IR) treatment would improve Default Mode Network (DMN) within-connectivity. Method: Resting-state functional connectivity of the main nodes of DMN was evaluated in a highly homogeneous sample of 18 drug-naive male adult participants with ADHD. Results: Comparing resting-state functional connectivity functional magnetic resonance imaging (R-fMRI) scans before and after MPH treatment focusing exclusively on within-DMN connectivity, we evidenced the strengthening of functional connectivity between two nodes of the DMN: posterior cingulate cortex (PCC) and left lateral parietal cortex (LLP). Conclusion: Our results contribute to the further understanding on how MPH affects functional connectivity within DMN of male adults with ADHD and corroborate the hypothesis of ADHD being a delayed neurodevelopmental disorder.

引用

页码：447 / 455

页数：9

共 53 条

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