pH-sensitive core-shell electrospun nanofibers based on polyvinyl alcohol/polycaprolactone as a potential drug delivery system for the chemotherapy against cervical cancer

被引：72

作者：

Yan, Eryun ^{[1
]}

Jiang, Jinyu ^{[1
]}

Yang, Xiuying ^{[1
]}

Fan, Liquan ^{[1
]}

Wang, Yuwei ^{[1
]}

An, Qinglong ^{[1
]}

Zhang, Zuoyuan ^{[1
]}

Lu, Borong ^{[1
]}

Wang, Dianyu ^{[1
]}

Zhang, Deqing ^{[1
]}

机构：

[1] Qiqihar Univ, Coll Mat Sci & Engn, Heilongjiang Prov Key Lab Polymer Composite Mat, Qiqihar 161006, Peoples R China

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2020年 / 55卷

关键词：

Polyvinyl alcohol; Polycaprolactone; Electrospinning; Chemotherapy; IN-VITRO; CONTROLLED-RELEASE; FABRICATION; HALLOYSITE; SCAFFOLDS; POLYMERS; CARRIER; PCL;

D O I：

10.1016/j.jddst.2019.101455

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

pH-sensitive polyvinyl alcohol/polycaprolactone (PVA/PCL) core-shell nanofibers were successfully fabricated by coaxial electrospinning method, in which PVA and PCL formed the core and shell layers, respectively. The core-shell microstructure of the fibers was certified by transmission electron microscopy (TEM). With the change of the feed ratio between PVA and PCL, there was little difference on the surface morphology of the fibers. FT-IR results indicated that there was no chemical interaction between PVA and PCL in the fibers. The as-prepared fibers can be used as a carrier for anticancer agent doxorubicin (DOX), which showed sustained and pH-responsive release of the drug. In addition, the DOX loaded fibers presented excellent performance against cervical cancer Hela cells. Such pH-sensitive nanofibers, which can degrade effectively in either acidic or neutral condition, have great potential for application in biomedical related fields.

引用

页数：8

共 28 条

[1] Drug delivery systems: Entering the mainstream [J].

Allen, TM ;

Cullis, PR .

SCIENCE, 2004, 303 (5665) :1818-1822

[2]

Asane GS, 2008, DRUG DEV IND PHARM, V34, P1246, DOI [10.1080/03639040802026012, 10.1080/03639040802026012 ]

[3] In vitro and in vivo degradation of non-woven materials made of poly(ε-caprolactone) nanofibers prepared by electrospinning under different conditions [J].

Bölgen, N ;

Menceloglu, YZ ;

Acatay, K ;

Vargel, I ;

Piskin, E .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2005, 16 (12) :1537-1555

[4] Nanohydrogel Formation within the Halloysite Lumen for Triggered and Sustained Release [J].

Cavallaro, Giuseppe ;

Lazzara, Giuseppe ;

Milioto, Stefana ;

Parisi, Filippo ;

Evtugyn, Vladimir ;

Rozhina, Elvira ;

Fakhrullin, Rawil .

ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (09) :8265-8273

[5]

Ghosh P. K., 2006, Current Drug Delivery, V3, P167, DOI 10.2174/156720106776359168

[6] Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO) [J].

Heunis, Tiaan ;

Bshena, Osama ;

Klumperman, Bert ;

Dicks, Leon .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 12 (04) :2158-2173

[7] Hydrogels for biomedical applications [J].

Hoffman, Allan S. .

ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 :18-23

[8]

Jabbar W.A., 2010, Journal of the Arkansas Academy of Science, V64, P101

[9] Biodegradable block copolymers as injectable drug-delivery systems [J].

Jeong, B ;

Bae, YH ;

Lee, DS ;

Kim, SW .

NATURE, 1997, 388 (6645) :860-862

[10] Electrospun PCL in Vitro: a Microstructural Basis for Mechanical Property Changes [J].

Johnson, Jed ;

Niehaus, Andy ;

Nichols, Sylvain ;

Lee, David ;

Koepsel, Justin ;

Anderson, David ;

Lannutti, John .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2009, 20 (04) :467-481

← 1 2 3 →