Dietary Intake of Acrylamide and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort

被引：10

作者：

Obon-Santacana, Mireia ^{[1
]}

Peeters, Petra H. M. ^{[2
,3
]}

Freisling, Heinz ^{[4
]}

Dossus, Laure ^{[5
,6
,7
]}

Clavel-Chapelon, Francoise ^{[5
,6
,7
]}

Baglietto, Laura ^{[8
,9
]}

Schock, Helena ^{[10
]}

Fortner, Renee T. ^{[10
]}

Boeing, Heiner ^{[11
]}

Tjonneland, Anne ^{[12
]}

Olsen, Anja ^{[12
]}

Overvad, Kim ^{[13
]}

Menendez, Virginia ^{[14
]}

Sanchez, Maria-Jose ^{[15
,16
]}

Larranaga, Nerea ^{[16
,17
]}

Huerta Castano, Jose Mara ^{[16
,18
]}

Barricarte, Aurelio ^{[19
]}

Khaw, Kay-Tee ^{[20
]}

Wareham, Nick ^{[21
]}

Travis, Ruth C. ^{[22
]}

Merritt, Melissa A. ^{[2
]}

Trichopoulou, Antonia ^{[23
,24
]}

Trichopoulos, Dimitrios ^{[23
,24
,25
]}

Orfanos, Philippos ^{[23
,26
]}

Masala, Giovanna ^{[27
]}

Sieri, Sabina ^{[28
]}

Tumino, Rosario ^{[29
]}

Vineis, Paolo ^{[2
,30
]}

Mattiello, Amalia ^{[31
]}

Bueno-de-Mesquita, H. B. ^{[2
,32
,33
,34
]}

Onland-Moret, N. Charlotte ^{[3
]}

Wirfalt, Elisabeth ^{[35
]}

Stocks, Tanja ^{[35
,36
]}

Idahl, Annika ^{[37
,38
]}

Lundin, Eva ^{[39
]}

Skeie, Guri ^{[40
]}

Gram, Inger T. ^{[40
]}

Weiderpass, Elisabete ^{[40
,41
,42
,43
]}

Riboli, Elio ^{[2
]}

Duell, Eric J. ^{[1
]}

机构：

[1] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona, Spain

[2] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[3] Univ Med Ctr, Dept Epidemiol, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[4] Int Agcy Res Canc, Dietary Exposure Assessment Grp, F-69372 Lyon, France

[5] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Nutr Hormones & Womens Hlth Team, U1018, Villejuif, France

[6] Univ Paris 11, UMRS 1018, Villejuif, France

[7] IGR, Villejuif, France

[8] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[9] Univ Melbourne, Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia

[10] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[11] German Inst Human Nutr, Dept Epidemiol, Potsdam, Nuthetal, Germany

[12] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[13] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[14] Publ Hlth Directorate, Asturias, Spain

[15] Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Granada Granada Ibs, Granada, Spain

[16] CIBER Epidemiol Salud Publ, Consortium Biomed Res Epidemiol & Publ Hlth, Madrid, Spain

[17] Publ Hlth Div Gipuzkoa BIODONOSTIA, Basque Reg Hlth Dept, Murcia, Spain

[18] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[19] Navarre Publ Hlth Inst, Pamplona, Spain

[20] Univ Cambridge, Sch Clin Med, Cambridge, England

[21] Univ Cambridge, MRC, Epidemiol Unit, Cambridge, England

[22] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[23] Hellen Hlth Fdn, Athens, Greece

[24] Acad Athens, Bur Epidemiol Res, Athens, Greece

[25] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[26] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[27] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[28] Fdn IRCSS Ist Nazl Tumori, Fdn IRCSS, Milan, Italy

[29] Civ MP Arezzo Hosp, Canc Registry & Histopathol Unit, Asp Ragusa, Italy

[30] Human Genet Fdn, Turin, Italy

[31] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[32] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[33] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[34] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[35] Lund Univ, Dept Clin Sci, Malmo, Sweden

[36] Umea Univ, Dept Perioperat & Surg Sci, S-90187 Umea, Sweden

[37] Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden

[38] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[39] Umea Univ, Dept Med Biosci, Umea, Sweden

[40] UiT Artic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[41] Canc Registry Norway, Oslo, Norway

[42] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[43] Folkhalsan Res Ctr, Dept Genet Epidemiol, Helsinki, Finland

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2015年 / 24卷 / 01期

基金：

英国医学研究理事会;

关键词：

HEMOGLOBIN ADDUCTS; EXPOSURE; GLYCIDAMIDE; ENDOMETRIAL; BIOMARKERS; VALIDITY; SMOKING; HUMANS; BREAST;

D O I：

10.1158/1055-9965.EPI-14-0636

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acrylamide, classified in 1994 by the International Agency for Research on Cancer (IARC) as "probably carcinogenic" to humans, was discovered in 2002 in some heat-treated, carbohydrate-rich foods. The association between dietary acrylamide intake and epithelial ovarian cancer risk (EOC) has been previously studied in one case-control and three prospective cohort studies which obtained inconsistent results and could not further examine histologic subtypes other than serous EOC. The present study was carried out in the European Prospective Investigation into Cancer and Nutrition (EPIC) subcohort of women (n = 325,006). Multivariate Cox proportional hazards models were used to assess the association between questionnaire-based acrylamide intake and EOC risk. Acrylamide was energy-adjusted using the residual method and was evaluated both as a continuous variable (per 10 mu g/d) and in quintiles; when subgroups by histologic EOC subtypes were analyzed, acrylamide intake was evaluated in quartiles. During a mean follow-up of 11 years, 1,191 incident EOC cases were diagnosed. At baseline, the median acrylamide intake in EPIC was 21.3 mu g/d. No associations and no evidence for a dose-response were observed between energy-adjusted acrylamide intake and EOC risk (HR10 mu(g/d), 1.02; 95% CI, 0.96-1.09; HRQ5vsQ1, 0.97; 95% CI, 0.76-1.23). No differences were seen when invasive EOC subtypes (582 serous, 118 endometrioid, and 79 mucinous tumors) were analyzed separately. This study did not provide evidence that acrylamide intake, based on food intake questionnaires, was associated with risk for EOC in EPIC. Additional studies with more reliable estimates of exposure based on biomarkers may be needed. (C) 2014 AACR.

引用

页码：291 / 297

页数：7

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