The effect of sex on multiple sclerosis risk and disease progression

被引：72

作者：

Voskuhl, Rhonda R. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Neurol, Neurosci Res Bldg 1,635 Charles E Young Dr South, Los Angeles, CA 90095 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2020年 / 26卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Multiple sclerosis; sex differences; neuroimaging; neuroimmunology; neurodegeneration; experimental autoimmune encephalomyelitis; CHROMOSOME COMPLEMENT; COGNITIVE IMPAIRMENT; NATURAL-HISTORY; CUTTING EDGE; DISABILITY; MEN; SUSCEPTIBILITY; TESTOSTERONE; DIMORPHISM; AGE;

D O I：

10.1177/1352458519892491

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sex differences in the incidence or severity of disease characterize many autoimmune and neurodegenerative diseases. Multiple sclerosis is a complex disease with both autoimmune and neurodegenerative aspects and is characterized by sex differences in susceptibility and progression. Research in the study sex differences is a way to capitalize on a known clinical observation, mechanistically disentangle it at the laboratory bench, then translate basic research findings back to the clinic as a novel treatment trial tailored to optimally benefit each sex. This "Bedside to Bench to Bedside" approach based on sex differences in MS will be reviewed here, first for disease susceptibility then for disability progression.

引用

页码：554 / 560

页数：7

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