New insights into the molecular mechanisms of general anaesthetics

被引：85

作者：

Chau, P-L ^{[1
]}

机构：

[1] Inst Pasteur, CNRS, URA 2185, F-75724 Paris, France

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2010年 / 161卷 / 02期

关键词：

general anaesthetics; pressure reversal; GABA receptor; glycine receptor; NMDA receptor; membrane; ION-CHANNEL PROTEIN; LATERAL PRESSURE PROFILES; D-ASPARTATE RECEPTOR; NICOTINIC ACETYLCHOLINE-RECEPTOR; LABELED PHOSPHOLIPID VESICLES; RECOMBINANT NMDA RECEPTORS; CENTRAL NERVOUS-SYSTEM; RECTIFIER K+ CHANNEL; GABA(A) RECEPTOR; A RECEPTOR;

D O I：

10.1111/j.1476-5381.2010.00891.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper provides new insights of how general anaesthetic research should be carried out in the future by an analysis of what we know, what we do not know and what we would like to know. I describe previous hypotheses on the mechanism of action of general anaesthetics (GAs) involving membranes and protein receptors. I provide the reasons why the GABA type A receptor, the NMDA receptor and the glycine receptor are strong candidates for the sites of action of GAs. I follow with a review on attempts to provide a mechanism of action, and how future research should be conducted with the help of physical and chemical methods.

引用

页码：288 / 307

页数：20

共 179 条

[1] A Transmembrane Residue Influences the Interaction of Propofol with the Strychnine-Sensitive Glycine α1 and α1β Receptor [J].