A Multitheragnostic Nanobubble System to Induce Blood-Brain Barrier Disruption with Magnetically Guided Focused Ultrasound

被引：95
作者：
Huang, Hsin-Yang [1 ]
Liu, Hao-Li [2 ]
Hsu, Po-Hung [2 ]
Chiang, Chih-Sheng [1 ]
Tsai, Chih-Hung [2 ]
Chi, Huei-Shang [1 ]
Chen, San-Yuan [1 ]
Chen, You-Yin [3 ]
机构：
[1] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 300, Taiwan
[2] Chang Gung Univ, Dept Elect Engn, Taoyuan, Taiwan
[3] Natl Yang Ming Univ, Dept Biomed Engn, Taipei 112, Taiwan
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 04期
关键词：
focused ultrasound; magnetic guidance; brain-blood barrier; nanobubbles; DRUG-DELIVERY; GLIOMA TREATMENT; IN-VIVO; MICROBUBBLES; MECHANISMS; THERAPY; AGENTS; HIFU;
D O I：
10.1002/adma.201403889
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic-resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system. © Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：655 / 661
页数：7
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