Role of hedgehog signaling related non-coding RNAs in developmental and pathological conditions

被引：8
作者：
HajiEsmailPoor, Zanyar [1 ]
Tabnak, Peyman [1 ]
Ahmadzadeh, Behnam [2 ]
Ebrahimi, Seyedeh Sanaz [3 ]
Faal, Bahareh [4 ]
Mashatan, Noushin [5 ]
机构：
[1] Tabriz Univ Med Sci, Fac Med, Tabriz, Iran
[2] Islamic Azad Univ, Fac Basic Sci, Dept Microbiol, Zanjan, Iran
[3] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Biochem, Tehran Med Sci, Tehran, Iran
[4] Islamic Azad Univ, Dept Biol, Cent Tehran Branch, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Sch Pharm, Grad, Tehran, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 153卷
关键词：
ncRNA; miRNA; lncRNA; circRNA; Cancer; Development; Hedgehog pathway; Signaling pathway; HEPATOCELLULAR-CARCINOMA CELLS; TO-MESENCHYMAL TRANSITION; MULTIPLE-MYELOMA CELLS; HUMAN CERVICAL-CANCER; SONIC HEDGEHOG; TUMOR-SUPPRESSOR; DOWN-REGULATION; GASTRIC-CANCER; NASOPHARYNGEAL CARCINOMA; INHIBITS PROLIFERATION;
D O I：
10.1016/j.biopha.2022.113507
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The hedgehog (Hh) signaling pathway is an evolutionarily conserved pathway that regulates embryonic development in vertebrates. However, strong evidence suggests the role of its dysregulation in human diseases, especially cancers. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), belong to a group of human transcriptomes that do not translate into proteins. However, they can highly influence protein expression. This review will provide a comprehensive link between ncRNAs and Hh signaling pathways in different human diseases and development, providing insights into disease and cancer progression as well as emphasizing their therapeutic, prognostic, and diagnostic significance.
引用
收藏
页数：16
相关论文
共 210 条
  • [1] Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy
    Aberger, Fritz
    Ruiz i Altaba, Ariel
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2014, 33 : 93 - 104
  • [2] miR-20a regulates proliferation, differentiation and apoptosis in P19 cell model of cardiac differentiation by targeting Smoothened
    Ai, Feng
    Zhang, Yanwei
    Peng, Bangtian
    [J]. BIOLOGY OPEN, 2016, 5 (09): : 1260 - 1265
  • [3] An J., 2022, FRONT ONCOL, P12
  • [4] Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
    Angulo, Pablo
    Kaushik, Gaurav
    Subramaniam, Dharmalingam
    Dandawate, Prasad
    Neville, Kathleen
    Chastain, Katherine
    Anant, Shrikant
    [J]. JOURNAL OF HEMATOLOGY & ONCOLOGY, 2017, 10
  • [5] Epithelial stem cells, wound healing and cancer
    Arwert, Esther N.
    Hoste, Esther
    Watt, Fiona M.
    [J]. NATURE REVIEWS CANCER, 2012, 12 (03) : 170 - 180
  • [6] Targeting of the signal transducer Smo links microRNA-326 to the oncogenic Hedgehog pathway in CD34+ CML stem/progenitor cells
    Babashah, Sadegh
    Sadeghizadeh, Majid
    Hajifathali, Abbas
    Tavirani, Mostafa Rezaei
    Zomorod, Mina Soufi
    Ghadiani, Mojtaba
    Soleimani, Masoud
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2013, 133 (03) : 579 - 589
  • [7] HOTAIR and androgen receptor synergistically increase GLI2 transcription to promote tumor angiogenesis and cancer stemness in renal cell carcinoma
    Bai, Ji-Yu
    Jin, Ben
    Ma, Jian-Bin
    Liu, Tian-Jie
    Yang, Chao
    Chong, Yue
    Wang, Xinyang
    He, Dalin
    Guo, Peng
    [J]. CANCER LETTERS, 2021, 498 : 70 - 79
  • [8] Hedgehog Signaling in Pancreatic Fibrosis and Cancer
    Bai, Yongyu
    Bai, Yongheng
    Dong, Jiaojiao
    Li, Qiang
    Jin, Yuepeng
    Chen, Bicheng
    Zhou, Mengtao
    [J]. MEDICINE, 2016, 95 (10)
  • [9] The crosstalk of hedgehog, PI3K and Wnt pathways in diabetes
    Benchoula, Khaled
    Parhar, Ishwar S.
    Wong, Eng Hwa
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2021, 698
  • [10] Cell-lineage specificity of primary cilia during postnatal epididymal development
    Bernet, Agathe
    Bastien, Alexandre
    Soulet, Denis
    Jerczynski, Olivia
    Roy, Christian
    Alves, Maira Bianchi Rodrigues
    Lecours, Cynthia
    Tremblay, Marie-Eve
    Bailey, Janice L.
    Robert, Claude
    Belleannee, Clemence
    [J]. HUMAN REPRODUCTION, 2018, 33 (10) : 1829 - 1838
12345678910