Synergistic antithrombotic effect of a combination of NO donor and plasma kallikrein inhibitor

被引：3

作者：

Ikarugi, H

Inoue, A

Yamashita, T

Tsuda, Y

Okada, Y

Ishii, H

Yamamoto, J

机构：

[1] Kobe Gakuin Univ, Fac Nutr, Physiol Lab, Kobe, Hyogo 6512180, Japan

[2] Kobe Gakuin Univ, High Technol Res Ctr, Kobe, Hyogo 6512180, Japan

[3] Univ Hyogo, Lab Hlth & Sport Sci, Kobe, Hyogo, Japan

[4] Kobe Gakuin Univ, Fac Pharmaceut Sci, Physiol Lab, Kobe, Hyogo 6512180, Japan

[5] Ishii Hosp, Med Corp Jinkeikai, Akashi, Hyogo, Japan

来源：

THROMBOSIS RESEARCH | 2005年 / 116卷 / 05期

关键词：

thrombolysis; thrombosis; platelets; nitric oxide; plasma kallikrein inhibitor;

D O I：

10.1016/j.thromres.2005.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the present study was to investigate the effect of a NO donor (GSNO) and a plasma kallikrein inhibitor (PKSI-527) atone and in combination on global haemostatic status. A new in vitro test was employed which allows the measurement of both platelet function and spontaneous thrombolysis. Sixteen healthy young and 18 elderly volunteers were enrolled in this study. When GSNO (1 mM) or PKSI-527 (20 mu M) was added to native human blood, platelet reactivity was significantly inhibited in both age groups. The combination of GSNO and PKSI-527 had additive inhibitory effect on platelets. Addition of either GSNO or PKSI-527 to blood samples did not significantly affect spontaneous thrombolysis, white added together, spontaneous thrombolysis was significantly enhanced. The thrombolysis enhancing effect was more prominent in elderly subjects. Our present findings suggest that the combination of NO donor and plasma kallikrein inhibitor may have clinical antithrombotic potential. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：403 / 408

页数：6

共 23 条

[21] Shear-induced in-vitro haemostasis/thrombosis tests: the benefit of using native blood [J].