Stem cell homing: From physiology to therapeutics

被引：174

作者：

Liesveld, Jane L. ^{[1
]}

Sharma, Naman ^{[1
]}

Aljitawi, Omar S. ^{[1
]}

机构：

[1] Univ Rochester, Dept Med, James P Wilmot Canc Inst, Rochester, NY USA

来源：

STEM CELLS | 2020年 / 38卷 / 10期

关键词：

cell migration; hematopoietic stem cells; homing; mobilization; MSCs; HEMATOPOIETIC STEM/PROGENITOR CELLS; MESENCHYMAL STROMAL CELLS; CORD BLOOD-CELLS; BONE-MARROW; ENDOTHELIAL-CELLS; PROGENITOR CELLS; CD34(+) CELLS; P-SELECTIN; ENHANCES ENGRAFTMENT; MIGRATORY CAPACITY;

D O I：

10.1002/stem.3242

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Stem cell homing is a multistep endogenous physiologic process which is also used by exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep process involves cell migration and is essential for hematopoietic stem cell transplantation. The process can be manipulated to enhance ultimate engraftment potential, and understanding stem cell homing is also important to the understanding of stem cell mobilization. Homing is also of potential importance in the recruitment of marrow mesenchymal stem and stromal cells (MSCs) to sites of injury and regeneration. This process is less understood but assumes importance when these cells are used for repair purposes. In this review, the process of HSPC and MSC homing is examined as are methods to enhance this process.

引用

页码：1241 / 1253

页数：13

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