Antimony(V) and Bismuth(V) Complexes of Lapachol: Synthesis, Crystal Structure and Cytotoxic Activity

被引：50

作者：

de Oliveira, Ludmila G. ^{[1
]}

Silva, Meiriane M. ^{[1
]}

de Paula, Flavia C. S. ^{[1
]}

Pereira-Maia, Elene C. ^{[1
]}

Donnici, Claudio L. ^{[1
]}

de Simone, Carlos A. ^{[3
]}

Frezard, Frederic ^{[4
]}

da Silva Junior, Eufranio N. ^{[1
,2
]}

Demicheli, Cynthia ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Quim, Inst Ciencias Exatas, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Lab Quim Sintet & Heterocicl, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Sao Paulo, Inst Fis, Dept Fis & Informat, BR-13560970 Sao Carlos, SP, Brazil

[4] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, BR-31270901 Belo Horizonte, MG, Brazil

来源：

MOLECULES | 2011年 / 16卷 / 12期

关键词：

antimony(V) complex; bismuth(V) complex; lapachol; cytotoxicity; cancer; IN-VITRO; DIPHENYLANTIMONY(III) DERIVATIVES; ORGANOBISMUTH COMPOUNDS; BETA-LAPACHONE; LIGANDS; ANALOGS; NAPHTHOQUINONES; PERSPECTIVES; CHEMISTRY; ONCOLOGY;

D O I：

10.3390/molecules161210314

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimony(V) and bismuth(V) complexes of lapachol have been synthesized by the reaction of Ph3SbCl2 or Ph3BiCl2 with lapachol (Lp) and characterized by several physicochemical techniques such as IR, and NMR spectroscopy and X-ray crystallography. The compounds contain six-coordinated antimony and bismuth atoms. The antimony(V) complex is a monomeric derivative, (Lp)(Ph3Sb)OH, and the bismuth(V) complex is a dinuclear compound bridged by an oxygen atom, (Lp)2(Ph3Bi)(2)O. Both compounds inhibited the growth of a chronic myelogenous leukemia cell line and the complex of Bi(V) was about five times more active than free lapachol. This work provides a rare example of an organo-Bi(V) complex showing significant cytotoxic activity.

引用

页码：10314 / 10323

页数：10

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