PCSK9 function and physiology

被引：71

作者：

Peterson, Andrew S. ^{[1
]}

Fong, Loren G. ^{[2
]}

Young, Stephen G. ^{[2
]}

机构：

[1] Genentech Inc, Dept Mol Biol, San Francisco, CA USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

来源：

JOURNAL OF LIPID RESEARCH | 2008年 / 49卷 / 06期

关键词：

D O I：

10.1194/jlr.E800008-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1152 / 1156

页数：5

共 38 条

[1] Mutations in PCSK9 cause autosomal dominant hypercholesterolemia [J].

Abifadel, M ;

Varret, M ;

Rabès, JP ;

Allard, D ;

Ouguerram, K ;

Devillers, M ;

Cruaud, C ;

Benjannet, S ;

Wickham, L ;

Erlich, D ;

Derré, A ;

Villéger, L ;

Farnier, M ;

Beucler, I ;

Bruckert, E ;

Chambaz, J ;

Chanu, B ;

Lecerf, JM ;

Luc, G ;

Moulin, P ;

Weissenbach, J ;

Prat, A ;

Krempf, M ;

Junien, C ;

Seidah, NG ;

Boileau, C .

NATURE GENETICS, 2003, 34 (02) :154-156

[2] Serum proprotein convertase subtilisin Kexin type 9 is correlated directly with serum LDL cholesterol [J].

Alborn, William E. ;

Cao, Guoqing ;

Careskey, Holly E. ;

Qian, Yue-Wei ;

Subramaniam, Danise R. ;

Davies, Julian ;

Conner, Elaine M. ;

Konrad, Robert J. .

CLINICAL CHEMISTRY, 2007, 53 (10) :1814-1819

[3] NARC-1/PCSK9 and its natural mutants -: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol [J].

Benjannet, S ;

Rhainds, D ;

Essalmani, R ;

Mayne, J ;

Wickham, L ;

Jin, WJ ;

Asselin, MC ;

Hamelin, J ;

Varret, M ;

Allard, D ;

Trillard, M ;

Abifadel, M ;

Tebon, A ;

Attie, AD ;

Rader, DJ ;

Boileau, C ;

Brissette, L ;

Chrétien, M ;

Prat, A ;

Seidah, NG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (47) :48865-48875

[4] Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy [J].

Berge, KE ;

Ose, L ;

Leren, TP .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (05) :1094-1100

[5] LIPOPROTEIN RECEPTORS IN THE LIVER - CONTROL SIGNALS FOR PLASMA-CHOLESTEROL TRAFFIC [J].

BROWN, MS ;

GOLDSTEIN, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1983, 72 (03) :743-747

[6] Biomedicine - Lowering LDL - Not only how low, but how long? [J].

Brown, MS ;

Goldstein, JL .

SCIENCE, 2006, 311 (5768) :1721-1723

[7] Effect of mutations in the PCSK9 gene on the cell surface LDL receptors [J].

Cameron, J ;

Holla, OL ;

Ranheim, T ;

Kulseth, MA ;

Berge, KE ;

Leren, TP .

HUMAN MOLECULAR GENETICS, 2006, 15 (09) :1551-1558

[8] Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9 [J].

Careskey, Holly E. ;

Davis, R. Aleks ;

Alborn, William E. ;

Troutt, Jason S. ;

Cao, Guoqing ;

Konrad, Robert J. .

JOURNAL OF LIPID RESEARCH, 2008, 49 (02) :394-398

[9] Low LDL cholesterol in African Americans resulting from frequent nonsense mutations in PCSK9 [J].

Cohen, J ;

Pertsemlidis, A ;

Kotowski, IK ;

Graham, R ;

Garcia, CK ;

Hobbs, HH .

NATURE GENETICS, 2005, 37 (03) :328-328

[10] Sequence variations in PCSK9, low LDL, and protection against coronary heart disease [J].

Cohen, JC ;

Boerwinkle, E ;

Mosley, TH ;

Hobbs, HH .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (12) :1264-1272

← 1 2 3 4 →