Resequencing and mutational analysis using oligonucleotide microarrays

被引：370

作者：

Hacia, JG ^{[1
]}

机构：

[1] NHGRI, Genet & Mol Biol Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE GENETICS | 1999年 / 21卷 / Suppl 1期

关键词：

D O I：

10.1038/4469

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Oligonucleotide microarray (DNA chip)-based hybridization analysis is a promising new technology which potentially allows rapid and cost-effective screens for all possible mutations and sequence variations in genomic DNA. Here, I review current strategies and uses for DNA chip-based resequencing and mutational analysis, the underlying principles of experimental designs, and future efforts to improve the sensitivity and specificity of chip-based assays.

引用

页码：42 / 47

页数：6

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