Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women

被引：68

作者：

Huerta-Chagoya, Alicia ^{[1
]}

Vazquez-Cardenas, Paola ^{[1
]}

Moreno-Macias, Hortensia ^{[3
]}

Tapia-Maruri, Leonardo ^{[1
]}

Rodriguez-Guillen, Rosario ^{[1
]}

Lopez-Vite, Erika ^{[4
]}

Garcia-Escalante, Guadalupe ^{[5
]}

Escobedo-Aguirre, Fernando ^{[6
]}

Parra-Covarrubias, Adalberto ^{[7
]}

Cordero-Brieno, Roberto ^{[8
]}

Manzo-Carrillo, Lizette ^{[8
]}

Zacarias-Castillo, Rogelio ^{[8
]}

Vargas-Garcia, Carlos ^{[9
]}

Aguilar-Salinas, Carlos ^{[2
]}

Tusie-Luna, Teresa ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Inst Invest Biomed, Unidad Biol Mol & Med Genom, Mexico City, DF, Mexico

[2] Inst Nacl Ciencias Med & Nutr Salcador Zubiran, Dept Endocrinol & Metab, Mexico City, DF, Mexico

[3] Univ Autonoma Metropolitana, Dept Econ, Mexico City, DF, Mexico

[4] Hosp Gen OHoran, Dept Ginelocol & Obstet, Merida, Yucatan, Mexico

[5] Univ Autonoma Yucatan, Dept Genet, Merida, Yucatan, Mexico

[6] Ctr Med Nacl 20 Noviembre, Dept Ginecol & Med Perinatal, Mexico City, DF, Mexico

[7] Inst Nacl Perinatol, Dept Endocrinol, Mexico City, DF, Mexico

[8] Hosp Gen Manuel Gea Gonzalez, Dept Obstet & Ginecol, Mexico City, DF, Mexico

[9] Ctr Invest Materno Infantil GEN, Dept Obstet & Ginecol, Mexico City, DF, Mexico

来源：

PLOS ONE | 2015年 / 10卷 / 05期

关键词：

GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; COMMON VARIANTS; SUSCEPTIBILITY LOCI; SEQUENCE VARIANTS; METAANALYSIS; EXPRESSION; TCF7L2; WEIGHT; KCNQ1;

D O I：

10.1371/journal.pone.0126408

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epidemiological and physiological similarities among Gestational Diabetes Mellitus (GDM) and Type 2 Diabetes (T2D) suggest that both diseases, share a common genetic background. T2D risk variants have been associated to GDM susceptibility. However, the genetic architecture of GDM is not yet completely understood. We analyzed 176 SNPs for 115 loci previously associated to T2D, GDM and body mass index (BMI), as well as a set of 118 Ancestry Informative Markers (AIMs), in 750 pregnant Mexican women. Association with GDM was found for two of the most frequently replicated T2D loci: a TCF7L2 haplotype (CTTC: rs7901695, rs4506565, rs7903146, rs12243326; P=2.16x10(-06); OR=2.95) and a KCNQ1 haplotype (TTT: rs2237892, rs163184, rs2237897; P=1.98x10(-05); OR=0.55). In addition, we found two loci associated to glycemic traits: CENTD2 (60' OGTT glycemia: rs1552224, P=0.03727) and MTNR1B (HOMA B: rs1387153, P=0.05358). Remarkably, a major susceptibility SLC16A11 locus for T2D in Mexicans was not shown to play a role in GDM risk. The fact that two of the main T2D associated loci also contribute to the risk of developing GDM in Mexicans, confirm that both diseases share a common genetic background. However, lack of association with a Native American contribution T2D risk haplotype, SLC16A11, suggests that other genetic mechanisms may be in play for GDM.

引用

页数：17

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