Evidence of Human Hantavirus Infection and Zoonotic Investigation of Hantavirus Prevalence in Rodents in Western Java']Java, Indonesia

被引：12

作者：

Kosasih, Herman ^{[1
]}

Ibrahim, Ima Nurisa ^{[2
]}

Wicaksana, Rudi ^{[3
]}

Alisjahbana, Bachti ^{[3
]}

Hoo, Yumilia ^{[4
]}

Yo, Iing H. ^{[4
]}

Antonjaya, Ungke ^{[1
]}

Widjaja, Susana ^{[1
]}

Winoto, Imelda ^{[1
]}

Williams, Maya ^{[1
]}

Blair, Patrick J. ^{[1
]}

机构：

[1] US Naval, Med Res Unit 2, Jakarta, Indonesia

[2] Natl Inst Hlth Res & Dev, Hlth Ecol Res & Dev Ctr, Jakarta, Indonesia

[3] Hasan Sadikin Hosp, Bandung, Indonesia

[4] Immanuel Hosp, Bandung, Indonesia

来源：

VECTOR-BORNE AND ZOONOTIC DISEASES | 2011年 / 11卷 / 06期

关键词：

Field studies; Hantavirus; Rattus; Zoonotic; HEMORRHAGIC-FEVER; RENAL SYNDROME; SEOUL; IDENTIFICATION; VIRUSES; PCR;

D O I：

10.1089/vbz.2010.0093

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

During febrile surveillance in the western Java City of Bandung, Indonesia, a patient with clinical symptoms consistent with hantavirus infection was found to have elevated titers of hantavirus-specific immunoglobulin M (IgM) and IgG antibodies. A subsequent epizoological investigation demonstrated a higher prevalence of hantavirus IgG antibodies in rodents trapped in the vicinity of the patient's home compared with rodents from a control area (13.2% vs. 4.7%, p = 0.036). The Old World Seoul hantavirus was detected by reverse transcriptase-polymerase chain reaction in the organs of 71% of the seropositive rodents tested. This is the first report of a Seoul virus infection in Indonesia supported by clinical, serological, and epizoological evidences. These findings suggest that hantavirus infection should be on the clinical differential diagnosis when acutely ill febrile patients report for care in western Java.

引用

页码：709 / 713

页数：5

共 12 条

[1] Identification of Dobrava, Hantaan, Seoul, and Puumala viruses by one-step real-time RT-PCR [J].