The Hedgehog's tale: developing strategies for targeting cancer

被引：321

作者：

Ng, Jessica M. Y. ^{[1
]}

Curran, Tom ^{[1
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 07期

基金：

美国国家卫生研究院;

关键词：

BASAL-CELL CARCINOMAS; PRIMITIVE NEUROECTODERMAL TUMORS; SMALL-MOLECULE MODULATION; GERM-LINE MUTATIONS; SONIC HEDGEHOG; HUMAN HOMOLOG; SIGNALING PATHWAY; STEM-CELLS; MOUSE MODELS; CANDIDATE GENE;

D O I：

10.1038/nrc3079

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Research into basic developmental biology has frequently yielded insights into cancer biology. This is particularly true for the Hedgehog (HH) pathway. Activating mutations in the HH pathway cause a subset of sporadic and familial, skin (basal cell carcinoma) and brain (medulloblastoma) tumours. Furthermore, the growth of many human tumours is supported by HH pathway activity in stromal cells. Naturally occurring and synthetic inhibitors of HH signalling show great promise in animal models and in early clinical studies. However, it remains unclear how many cancers will ultimately benefit from these new, molecularly targeted therapies.

引用

页码：493 / 501

页数：9

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