Ocular motor abnormalities in Parkinsonian syndromes

被引：64
作者：
Pinkhardt, Elmar H. [1 ]
Kassubek, Jan [1 ]
机构：
[1] Univ Ulm, Dept Neurol, D-89081 Ulm, Germany
来源：
PARKINSONISM & RELATED DISORDERS | 2011年 / 17卷 / 04期
关键词：
Parkinsonism; Parkinson's disease; Progressive supranuclear palsy; Multiple system atrophy; Oculomotor function; Video-oculography; PROGRESSIVE SUPRANUCLEAR PALSY; FRONTAL EYE FIELD; MULTIPLE SYSTEM ATROPHY; NIGRA PARS RETICULATA; MEMORY-GUIDED SACCADES; SUBTHALAMIC NUCLEUS STIMULATION; DORSOLATERAL PREFRONTAL CORTEX; LATERAL INTRAPARIETAL AREA; DRUG-INDUCED PARKINSONISM; SCLERAL SEARCH COILS;
D O I：
10.1016/j.parkreldis.2010.08.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Oculomotor abnormalities can be observed in all Parkinsonian syndromes (PS). Nevertheless, due to the considerable overlap of oculomotor pathology in Parkinsonism, oculomotor changes are not generally considered to contribute substantially to the differential diagnosis of PS. Here we review the characteristics of oculomotor disturbances in the major PS, we provide a survey of the current concepts of the underlying neural physiology of oculomotor control and a summary of the major recording techniques for eye movements. The main focus of this review is to outline the subtle differences between apparently similar oculomotor alterations in Parkinson's disease (PD) and atypical neurodegenerative PS that can contribute to the early differential diagnosis of these entities. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：223 / 230
页数：8
相关论文
共 107 条
[11]   Functional MRI mapping of occipital and frontal cortical activity during voluntary and imagined saccades [J].
BodisWollner, I ;
Bucher, SF ;
Seelos, KC ;
Paulus, W ;
Reiser, M ;
Oertel, WH .
NEUROLOGY, 1997, 49 (02) :416-420
[12]  
Braak H, 2006, J NEURAL TRANSM-SUPP, P89
[13]   Invited Article: Nervous system pathology in sporadic Parkinson disease [J].
Braak, Heiko ;
Del Tredici, Kelly .
NEUROLOGY, 2008, 70 (20) :1916-1925
[14]   Stanley Fahn Lecture 2005:: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered [J].
Braak, Heiko ;
Bohl, Juergen R. ;
Muller, Christian M. ;
Rub, Udo ;
de Vos, Rob A. I. ;
Del Tredici, Kelly .
MOVEMENT DISORDERS, 2006, 21 (12) :2042-2051
[15]   Control of voluntary and reflexive saccades in Parkinson's disease [J].
Briand, KA ;
Strallow, D ;
Hening, W ;
Poizner, H ;
Sereno, AB .
EXPERIMENTAL BRAIN RESEARCH, 1999, 129 (01) :38-48
[16]  
BRONSTEIN AM, 1991, BRAIN, V114, P1
[17]   Deficits in saccadic eye-movement control in Parkinson's disease [J].
Chan, F ;
Armstrong, IT ;
Pari, G ;
Riopelle, RJ ;
Munoz, DP .
NEUROPSYCHOLOGIA, 2005, 43 (05) :784-796
[18]   Cognitive deficits in multiple system atrophy correlate with frontal atrophy and disease duration [J].
Chang, C. C. ;
Chang, Y. Y. ;
Chang, W. N. ;
Lee, Y. C. ;
Wang, Y. L. ;
Lui, C. C. ;
Huang, C. W. ;
Liu, W. L. .
EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 (10) :1144-1150
[19]   Antisaccadic effects of a dopamine agonist as add-on therapy in advanced Parkinson's patients [J].
Crevits, L ;
Versijpt, J ;
Hanse, M ;
De Ridder, K .
NEUROPSYCHOBIOLOGY, 2000, 42 (04) :202-206
[20]   Muscimol-induced inactivation of monkey frontal eye field: Effects on visually and memory-guided saccades [J].
Dias, EC ;
Segraves, MA .
JOURNAL OF NEUROPHYSIOLOGY, 1999, 81 (05) :2191-2214
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